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Keywords: Progenitor
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Journal Articles
Journal: Development
Development (2020) 147 (1): dev182295.
Published: 13 January 2020
...Charles J. Sheehan; John J. McMahon; Lucas D. Serdar; Debra L. Silver ABSTRACT Embryonic interneuron development underlies cortical function and its disruption contributes to neurological disease. Yet the mechanisms by which viable interneurons are produced from progenitors remain poorly understood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev166454.
Published: 16 January 2019
...Thomas Volckaert; Tingting Yuan; Jie Yuan; Eistine Boateng; Seantel Hopkins; Jin-San Zhang; Victor J. Thannickal; Reinhard Fässler; Stijn P. De Langhe ABSTRACT Organ growth and tissue homeostasis rely on the proliferation and differentiation of progenitor cell populations. In the developing lung...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev162115.
Published: 21 September 2018
...Eric D. Bankaitis; Matthew E. Bechard; Guoqiang Gu; Mark A. Magnuson; Christopher V. E. Wright ABSTRACT During mouse pancreas organogenesis, endocrine cells are born from progenitors residing in an epithelial plexus niche. After a period in a lineage-primed Neurog3 LO state, progenitors become...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev163485.
Published: 15 August 2018
... modelling and drug screening (see Box 1 ). Moreover, iPSCs provide a gene-correctable cell source that may be useful for autologous transplantation, minimising the need for immunosuppression, although this remains a controversial hypothesis ( Liu et al., 2017 ). Anterior foregut endoderm progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev162305.
Published: 16 April 2018
... progenitors. We identify a proliferative trophoblast niche at the base of the cytotrophoblast cell columns in first trimester placentas that is characterised by integrin α2 (ITGA2) expression. Pulse-chase experiments with 5-iodo-2′-deoxyuridine indicate that these cells might contribute to both villous (VCT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev146829.
Published: 25 January 2018
...Shawn Liang; Ellen Johansson; Guillermo Barila; Daniel L. Altschuler; Henrik Fagman; Mikael Nilsson ABSTRACT The developmental program that regulates thyroid progenitor cell proliferation is largely unknown. Here, we show that branching-like morphogenesis is a driving force to attain final size of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev155861.
Published: 04 January 2018
...Zhanguo Gao; Alexes C. Daquinag; Fei Su; Brad Snyder; Mikhail G. Kolonin The relative abundance of thermogenic beige adipocytes and lipid-storing white adipocytes in adipose tissue underlie its metabolic activity. The roles of adipocyte progenitor cells, which express PDGFRα or PDGFRβ, in adipose...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1600–1606.
Published: 01 May 2017
...: During adult airway epithelial homeostasis in mice, FGFR2 signalling is required for self-renewing divisions of basal stem cells and to maintain expression of the key transcription factor SOX2. Cre-Lox Lung Mouse Trachea Progenitor Like human airways, the mouse trachea contains three...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 624–634.
Published: 15 February 2017
...Aileen R. Helsel; Qi-En Yang; Melissa J. Oatley; Tessa Lord; Fred Sablitzky; Jon M. Oatley Spermatogenesis is a classic model of cycling cell lineages that depend on a balance between stem cell self-renewal for continuity and the formation of progenitors as the initial step in the production of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2829–2841.
Published: 01 August 2016
.... Somatic deletion of Sip1 from mouse retinal progenitors primarily affects the generation of inner nuclear layer cell types, resulting in complete loss of horizontal cells and reduced numbers of amacrine and bipolar cells, while the number of Muller glia is increased. Molecular analysis places Sip1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2376–2388.
Published: 01 July 2016
...Sam Goldsmith; Robin Lovell-Badge; Karine Rizzoti Sox2 mutations are associated with pituitary hormone deficiencies and the protein is required for pituitary progenitor proliferation, but its function has not been well characterized in this context. SOX2 is known to activate expression of Six6...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 1859–1873.
Published: 01 June 2016
...Christopher P. Zelinka; Leo Volkov; Zachary A. Goodman; Levi Todd; Isabella Palazzo; William A. Bishop; Andy J. Fischer We investigate the roles of mTor signaling in the formation of Müller glia-derived progenitor cells (MGPCs) in the chick retina. During embryonic development, pS6 (a readout of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1390–1395.
Published: 15 April 2015
... of Biologists Ltd 2015 SUMMARY : This poster article summarises how lysophosphatidic acid is produced and metabolised during development, how it signals, and how it influences tissue and organ development. Lysophospholipid GPCR Progenitor Proliferation Differentiation Survival...
Journal Articles
Journal: Development
Development (2015) 142 (1): 21–30.
Published: 01 January 2015
...Michael A. Trembley; Lissette S. Velasquez; Karen L. de Mesy Bentley; Eric M. Small An important pool of cardiovascular progenitor cells arises from the epicardium, a single layer of mesothelium lining the heart. Epicardium-derived progenitor cell (EPDC) formation requires epithelial-to-mesenchymal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4418–4431.
Published: 01 December 2014
...Daniela Später; Emil M. Hansson; Lior Zangi; Kenneth R. Chien During development, cardiogenesis is orchestrated by a family of heart progenitors that build distinct regions of the heart. Each region contains diverse cell types that assemble to form the complex structures of the individual cardiac...
Journal Articles
Journal: Development
Development (2012) 139 (18): 3363–3372.
Published: 15 September 2012
...Philip A. Seymour; Hung Ping Shih; Nisha A. Patel; Kristine K. Freude; Ruiyu Xie; Christopher J. Lim; Maike Sander All mature pancreatic cell types arise from organ-specific multipotent progenitor cells. Although previous studies have identified cell-intrinsic and -extrinsic cues for progenitor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 1931–1940.
Published: 01 June 2012
...Ethan David Cohen; Mayumi F. Miller; Zichao Wang; Randall T. Moon; Edward E. Morrisey Wnt/β-catenin has a biphasic effect on cardiogenesis, promoting the induction of cardiac progenitors but later inhibiting their differentiation. Second heart field progenitors and expression of the second heart...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1557–1567.
Published: 01 May 2012
...Nikolay Ninov; Maxim Borius; Didier Y. R. Stainier Genetic studies have implicated Notch signaling in the maintenance of pancreatic progenitors. However, how Notch signaling regulates the quiescent, proliferative or differentiation behaviors of pancreatic progenitors at the single-cell level...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1235–1245.
Published: 01 April 2011
...Ying Tian; Yuzhen Zhang; Laura Hurd; Sridhar Hannenhalli; Feiyan Liu; Min Min Lu; Edward E. Morrisey The temporal and spatial control of organ-specific endoderm progenitor development is poorly understood. miRNAs affect cell function by regulating programmatic changes in protein expression levels...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1189–1203.
Published: 01 April 2010
...Sunny Hartwig; Jacqueline Ho; Priyanka Pandey; Kenzie MacIsaac; Mary Taglienti; Michael Xiang; Gil Alterovitz; Marco Ramoni; Ernest Fraenkel; Jordan A. Kreidberg The Wilms' tumor suppressor 1 ( WT1 ) gene encodes a DNA- and RNA-binding protein that plays an essential role in nephron progenitor...
Includes: Supplementary data