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Keywords: Prodomain
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Journal Articles

Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice

Anup Tilak, Sylvia M. Nelsen, Hyung-Seok Kim, Nathan Donley, Autumn McKnite, Hyunjung Lee, Jan L. Christian
Journal: Development
Development (2014) 141 (15): 3062–3071.
https://doi.org/10.1242/dev.110130
Published: 1 August 2014
...Anup Tilak; Sylvia M. Nelsen; Hyung-Seok Kim; Nathan Donley; Autumn McKnite; Hyunjung Lee; Jan L. Christian ProBMP4 is generated as a latent precursor that is sequentially cleaved at two sites within the prodomain to generate an active ligand. An initial cleavage occurs adjacent to the ligand...
View articletitled, Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice
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Includes: Supplementary data
Journal Articles

Essential role of Bmp7 ( snailhouse ) and its prodomain in dorsoventral patterning of the zebrafish embryo

Alexander Dick, Marc Hild, Hermann Bauer, Yoshiyuki Imai, Heike Maifeld, Alexander F. Schier, William S. Talbot, Tewis Bouwmeester, Matthias Hammerschmidt
Journal: Development
Development (2000) 127 (2): 343–354.
https://doi.org/10.1242/dev.127.2.343
Published: 15 January 2000
... here that zebrafish Bmp7 is disrupted in snailhouse ( snh ) mutants. The allele snh st1 is a translocation deleting the bmp7 gene, while snh ty68 displays a Val→Gly exhange in a conserved motif of the Bmp7 prodomain. The snh ty68 mutation is temperature-sensitive, leading to severalfold reduced...
View articletitled, Essential role of Bmp7 ( snailhouse ) and its prodomain in dorsoventral patterning of the zebrafish embryo
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