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Keywords: Primordial germ cell
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Journal Articles
Journal: Development
Development (2021) 148 (23): dev200093.
Published: 02 December 2021
...Christopher B. Cooke; Naomi Moris ABSTRACT Primordial germ cells (PGCs) form early in embryo development and are crucial precursors to functioning gamete cells. Considerable research has focussed on identifying the transcriptional characteristics and signalling pathway requirements that confer PGC...
Journal Articles
Journal: Development
Development (2021) 148 (8): dev198150.
Published: 16 April 2021
...? Integrating findings from diverse species, we conclude that the final commitment of the germline to gametogenesis – the process of germ cell determination – occurs after primordial germ cells (PGCs) colonize the gonads. Combining this understanding with medical findings, we present a model whereby germ cell...
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193060.
Published: 20 January 2021
...Stefan Redl; Antonio M. de Jesus Domingues; Edoardo Caspani; Stefanie Möckel; Willi Salvenmoser; Maria Mendez-Lago; René F. Ketting ABSTRACT Primordial germ cells (PGCs) are the precursors of germ cells, which migrate to the genital ridge during early development. Relatively little is known about...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev183798.
Published: 21 February 2020
...Toshihiro Kobayashi; Hisato Kobayashi; Teppei Goto; Tomoya Takashima; Mami Oikawa; Hiroki Ikeda; Reiko Terada; Fumika Yoshida; Makoto Sanbo; Hiromitsu Nakauchi; Kazuki Kurimoto; Masumi Hirabayashi ABSTRACT Primordial germ cells (PGCs), the founder cells of the germline, are specified in pre...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev164160.
Published: 03 December 2018
...Kentaro Mochizuki; Yukiko Tando; Tamotsu Sekinaka; Kei Otsuka; Yohei Hayashi; Hisato Kobayashi; Asuka Kamio; Yumi Ito-Matsuoka; Asuka Takehara; Tomohiro Kono; Noriko Osumi; Yasuhisa Matsui ABSTRACT In mouse embryos, primordial germ cells (PGCs) are fate-determined from epiblast cells. Signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev155663.
Published: 22 January 2018
... including: inhibition of specific transcription, degradation of specific mRNAs and inhibition of tissue morphogenesis. These results document a signaling mechanism required for the sequential restriction of germ cell factors, which causes a specific set of embryonic cells to become the primordial germ cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 928–934.
Published: 01 March 2017
...Lorna Taylor; Daniel F. Carlson; Sunil Nandi; Adrian Sherman; Scott C. Fahrenkrug; Michael J. McGrew In this work we use TALE nucleases (TALENs) to target a reporter construct to the DDX4 ( vasa ) locus in chicken primordial germ cells (PGCs). Vasa is a key germ cell determinant in many animal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 255–263.
Published: 15 January 2016
... of germ cells in mice. Our functional analyses of the Gryllus Blimp-1 ortholog revealed that it is essential for Gryllus primordial germ cell development, and is regulated by upstream input from the BMP signaling pathway. This functional conservation of the epistatic relationship between BMP signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (16): 2730–2739.
Published: 15 August 2015
.... The ‘last cell standing’ model describes primordial germ cell (PGC) development in axolotls, in which PGCs are maintained by an extracellular signalling niche, and germ line commitment occurs after gastrulation. Here, we propose that this ‘stochastic’ mode of PGC specification is conserved in vertebrates...
Journal Articles
Journal: Development
Development (2014) 141 (12): 2429–2440.
Published: 15 June 2014
..., in Xenopus and zebrafish embryos primordial germ cells (PGCs) are specified by germ plasm that is inherited from the egg; in mice, Blimp1 expression in the epiblast mediates the commitment of cells to the germ line. How these disparate mechanisms of PGC specification evolved is unknown. Here, in order...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (23): 4011–4020.
Published: 01 December 2009
...Shinpei Yamaguchi; Kazuki Kurimoto; Yukihiro Yabuta; Hiroyuki Sasaki; Norio Nakatsuji; Mitinori Saitou; Takashi Tada The pluripotency factor Nanog is expressed in peri-implantation embryos and primordial germ cells (PGCs). Nanog-deficient mouse embryos die soon after implantation. To explore...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (8): 1295–1303.
Published: 15 April 2009
...Ying Gu; Chris Runyan; Amanda Shoemaker; Azim Surani; Chris Wylie Steel factor is an essential survival and proliferation factor for primordial germ cells (PGCs) during their migration in the early mouse embryo. PGCs arise during gastrulation, and migrate into the posterior endoderm that becomes...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (1): 77–83.
Published: 01 January 2007
... in the mouse embryo commences in the primordial germ cells(PGCs) just after their formation, and a loss of this protein results in the germ cell-less phenotype in both sexes. By contrast, Nanos2 expression begins only in male PGCs after their entry into the genital ridge and a loss of this protein results...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (20): 5079–5089.
Published: 15 October 2004
...Miho Asaoka; Haifan Lin A fundamental yet unexplored question in stem cell biology is how the fate of tissue stem cells is initially determined during development. In Drosophila, germline stem cells (GSCs) descend from a subset of primordial germ cells (PGCs) at the onset of oogenesis. GSC...
Journal Articles
Journal: Development
Development (2003) 130 (26): 6423–6430.
Published: 29 December 2003
..., the mechanisms of germ cell specification in mice remain unknown. We located precursors to primordial germ cells (PGCs) within early embryos, and show here that cell-cell interaction among these precursors is required for germ cell specification. We found that the expression of a calcium-dependent cell adhesion...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (1986) 94 (1): 83–93.
Published: 01 June 1986
...J. H. Cleine The genital ridges of Xenopus laevis tadpoles reared from eggs kept in an inverted position contain less than 40 % of the number of primordial germ cells (PGCs) of controls (Cleine & Dixon, 1985). It has been suggested that this reduction is caused by the germ cells' ectopic...