... to commit to a hematopoietic fate. Here, we identify tril as a Gata2 target gene that is required in both ectoderm and mesoderm for primitive hematopoiesis to occur. Tril is a transmembrane protein that functions as a co-receptor for Toll-like receptors to mediate innate immune responses in the adult brain...

... the mechanisms of hematopoietic development in primates. * Author for correspondence (e-mail: tnakaha@kuhp.kyoto-u.ac.jp ) 8 1 2004 © 2004. 2004 ES cells Primate Primitive hematopoiesis Definitive hematopoiesis The ES cell line CMK6 was established from cynomolgus monkey...

..., have been described. However, a specific regulator of primitive hematopoiesis has yet to be reported. The zebrafish bloodless ( bls ) mutation causes absence of embryonic erythrocytes in a dominant but incompletely penetrant manner. Primitive macrophages appear to develop normally in bls mutants...