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Keywords: Primary cilia
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Journal Articles
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Neural development
Journal: Development
Development (2023) 150 (2): dev201116.
Published: 19 January 2023
... that neuronal primary cilia, known as ‘signaling antennas’, play crucial roles in the formation and maturation of neurons ( Youn and Han, 2018 ; Han et al., 2008 ) and the regulation of the early patterning of another neuronal tissue, the neural tube ( Caspary et al., 2007 ). Within the OE, primary cilia...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (21): dev199931.
Published: 31 October 2022
... manner, as well as defects in primary cilia. Furthermore, loss of PAR3 enhanced ligand-independent ciliary accumulation of smoothened and an inhibitor of smoothened ameliorated the hyperproliferation of NPCs in the telencephalon. Thus, these findings support the idea that PAR3 has a crucial role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev194175.
Published: 15 February 2021
...Christian Louis Bonatto Paese; Evan C. Brooks; Megan Aarnio-Peterson; Samantha A. Brugmann ABSTRACT Ciliopathies represent a growing class of diseases caused by defects in microtubule-based organelles called primary cilia. Approximately 30% of ciliopathies are characterized by craniofacial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev151407.
Published: 17 September 2018
... intervention in disease. Primary cilia Ciliopathies Cilium assembly Cilium disassembly Cancer Cilia and flagella are evolutionarily conserved hair-like microtubule-based structures that project from cells. These organelles are membrane bound and, although their membrane is contiguous...
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (12): 2160–2171.
Published: 15 June 2016
...Laura Grisanti; Ekaterina Revenkova; Ronald E. Gordon; Carlo Iomini Primary cilia have been linked to signaling pathways involved in cell proliferation, cell motility and cell polarity. Defects in ciliary function result in developmental abnormalities and multiple ciliopathies. Patients affected...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1491–1501.
Published: 1 May 2016
... birth owing to organogenesis defects as in ciliopathies. Shh signaling is impaired in null embryos and primary cilia are reduced in multiple tissues. We show that CP110 is required for anchoring of basal bodies to the membrane during cilia formation. CP110 loss resulted in an abnormal distribution...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (23): 4080–4091.
Published: 1 December 2015
... ) in the endocardium to promote trabeculation and that forced Notch activation in the absence of cardiac contraction rescues efnb2a and nrg1 expression. Using in vitro and in vivo systems, we showed that primary cilia are important mediators of fluid flow to stimulate Notch expression. Together, our findings describe...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 3003–3012.
Published: 1 August 2014
.... Although phenotypically similar to talpid 3 , talpid 2 has a distinct facial phenotype and an unknown cellular, molecular and genetic basis. We set out to determine the etiology of the craniofacial phenotype of this mutant. We confirmed that primary cilia were disrupted in talpid 2 mutants. Molecularly, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3261–3272.
Published: 1 August 2011
... regions, depending on hedgehog (Hh) signalling, and exhibits embryonic lethality. The talpid 3 chicken has a mutation in KIAA0586 , which encodes a centrosomal protein required for the formation of primary cilia, which are sites of vertebrate Hh signalling. The highly conserved exons 11 and 12 of KIAA0586...
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Journal Articles
Journal Articles