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Keywords: Prickle
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Journal Articles
Journal: Development
Development (2018) 145 (18): dev168112.
Published: 17 September 2018
... and interpret intercellular polarity signals: Dachsous/Fat, and the ‘core’ or Starry night/Frizzled system. Here, we study the prickle gene and its protein products Prickle and Spiny leg. Much research on PCP has focused on the asymmetric localisation of core proteins in the cell and as a result...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3429–3439.
Published: 01 October 2015
... proteins Van Gogh-like (Vangl) and Frizzled (Fzd), as well as the cytoplasmic effectors Prickle (Pk) and Dishevelled (Dvl). Asymmetric localization of these proteins is thought to be central to their function, and understanding the dynamics of these proteins is an important challenge in developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2866–2874.
Published: 15 July 2014
... alternative Prickle (Pk-Sple) protein isoforms control the polarity of this MT network. This function allows the isoforms of Pk-Sple to differentially determine the direction in which asymmetry is established and therefore, ultimately, the direction of tissue polarity. Oppositely oriented signals that are...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (3): 543–552.
Published: 01 February 2011
... signaling through Knypek (Glypican4/6) and Dishevelled components. Second, we tested whether microtubules are required for planar cell polarization. Once the planar cell polarity is established, microtubules are not required for accumulation of Prickle at the anterior cell edge. However, microtubules are...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (19): 4651–4664.
Published: 01 October 2004
...Peter A. Lawrence; José Casal; Gary Struhl The integument of the Drosophila adult abdomen bears oriented hairs and bristles that indicate the planar polarity of the epidermal cells. We study four polarity genes, frizzled ( fz ), prickle ( pk ), Van gogh/strabismus ( Vang/stbm ) and starry night...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (13): 3007–3014.
Published: 01 July 2003
... cell polarisation. We find that the Strabismus protein becomes asymmetrically localised to the proximal edge of cells. In the absence of strabismus activity, the planar polarity proteins Dishevelled and Prickle are mislocalised in the cell. We show that Strabismus binds directly to Dishevelled and...
Journal Articles
Journal: Development
Development (2003) 130 (9): 1877–1887.
Published: 01 May 2003
... strabismus tissue polarity phenotype by mutations in two other tissue polarity genes, flamingo and prickle . Flamingo is autonomously required for the establishment of ommatidial polarity. Its localization is dynamic throughout ommatidial development and is dependent on Frizzled and Notch. Flamingo and...