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Keywords: Presomitic mesoderm
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Journal Articles
Journal: Development
Development (2018) 145 (14): dev161091.
Published: 30 July 2018
... the progenitors which facilitate body axis elongation, and its activity is crucial for timing of the segmentation clock. Myc Neuromesodermal progenitors Segmentation clock Embryo Presomitic mesoderm The Myc proto-oncogene family is one of the most exhaustively studied families of vertebrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (6): dev157339.
Published: 19 March 2018
... Body skeletal muscles derive from the paraxial mesoderm, which forms in the posterior region of the embryo. Using microarrays, we characterize novel mouse presomitic mesoderm (PSM) markers and show that, unlike the abrupt transcriptome reorganization of the PSM, neural tube differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3808–3818.
Published: 15 October 2017
... and of the transcriptional co-activator SAGA, is required for the assembly of these complexes in the mouse embryo. We performed Taf10 conditional deletions during mesoderm development and show that Taf10 loss in the presomitic mesoderm (PSM) does not prevent cyclic gene transcription or PSM segmental patterning, whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2982–2993.
Published: 15 August 2017
...Richa Sharma; Maxwell E. R. Shafer; Eric Bareke; Mathieu Tremblay; Jacek Majewski; Maxime Bouchard ABSTRACT Caudal somites are generated from a pool of progenitor cells located in the tailbud region. These progenitor cells form the presomitic mesoderm that gradually differentiates into somites...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2260–2270.
Published: 01 June 2014
... and presomitic mesoderm. In the presence of RA, RARγ2 serves as an activator, facilitating somite differentiation. Treatment with an RARγ-selective inverse agonist (NRX205099) or overexpression of dominant-negative RARγ increases the expression of posterior Hox genes and that of marker genes for presomitic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (2): 277–287.
Published: 15 January 2012
...Laurent Yvernogeau; Gwenola Auda-Boucher; Josiane Fontaine-Perus We have combined the use of mouse genetic strains and the mouse-into-chicken chimera system to determine precisely the sequence of forelimb colonization by presomitic mesoderm (PSM)-derived myoblasts and angioblasts, and the possible...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (9): 1515–1522.
Published: 01 May 2010
..., suggesting the importance of the Notch on/off state for boundary formation. However, a recent study has shown that mouse embryos expressing Notch-intracellular domain (NICD) throughout the presomitic mesoderm (PSM) can still form more than ten somites, indicating that the NICD on/off state is dispensable...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (15): 2555–2562.
Published: 01 August 2008
...Masayuki Oginuma; Yasutaka Niwa; Deborah L. Chapman; Yumiko Saga The metameric structures in vertebrates are based on the periodicity of the somites that are formed one by one from the anterior end of the presomitic mesoderm (PSM). The timing and spacing of somitogenesis are regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3155–3165.
Published: 01 September 2007
...Pedro Rifes; Lara Carvalho; Catarina Lopes; Raquel P. Andrade; Gabriela Rodrigues; Isabel Palmeirim; Sólveig Thorsteinsdóttir The absence of ectoderm impairs somite formation in cultured presomitic mesoderm (PSM) explants, suggesting that an ectoderm-derived signal is essential for somitogenesis...
Journal Articles
Journal: Development
Development (2007) 134 (8): 1561–1569.
Published: 15 April 2007
... to this work 14 2 2007 © 2007. 2007 Somitogenesis Notch signaling Presomitic mesoderm Segmentation Somites are generated by sequential segregation of cell masses from the anterior part of the unsegmented presomitic mesoderm (PSM), in both a spatially and temporally coordinated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (14): 3391–3399.
Published: 15 July 2004
...Birgit Aerne; David Ish-Horowicz Segmentation in vertebrate embryos is controlled by a biochemical oscillator (`segmentation clock') intrinsic to the cells in the unsegmented presomitic mesoderm, and is manifested in cyclic transcription of genes involved in establishing somite polarity...
Journal Articles
Journal: Development
Development (2003) 130 (20): 4797–4807.
Published: 15 October 2003
... , but not Myf5 expression;however, we show that the source of the Wnt signal is intrinsic to the mesoderm. Gain- and loss-of-function experiments indicate that Wnt5b ,which is expressed in the presomitic mesoderm, represents the MyoD -activating cue. Despite Wnt5b expression in the presomitic mesoderm, MyoD...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3609–3619.
Published: 01 August 2002
... to all segments, from their most anterior to their most posterior borders. Therefore, it appears that mediolateral regionalisation of myotomal precursor cells is a property established before bilateralisation of the presomitic mesoderm and that coherent clonal growth accompanies cell dispersion along...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3693–3704.
Published: 01 August 2002
... insects and vertebrates. The anterior to posterior formation of somites from the presomitic mesoderm (PSM) is a highly dynamic process that underlies much of the segmentation of the adult. Many models of somitogenesis propose the existence of oscillatory behavior in the PSM as one method of creating...
Journal Articles
Journal: Development
Development (1986) 92 (1): 269–285.
Published: 01 March 1986
...P. P. L. Tam Consistently six to seven soniites were formed in explants of presomitic mesoderm of 8·5-day to 11·5-day mouse embryos and this number correlated well with the number of somitomeres previously identified in the same tissue by stereo SEM (Tam, Meier & Jacobson, 1982). During...