...Noah B. Goodson; Michael A. Kaufman; Ko U. Park; Joseph A. Brzezinski, IV ABSTRACT The transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcription factors Prdm1 and Vsx2 through cell type-specific enhancers. PRDM1...

... is still debated. Here, we identify a crucial role for the transcription factor PRDM1 in the orderly transition from epiblast to defined neural lineages in chick. PRDM1 is initially expressed broadly in the entire epiblast, but becomes gradually restricted as cell fates are specified. We find that PRDM1...

... mammary gland, Blimp1 marks a rare progenitor population, and is required for cell proliferation and polarity as well as efficient milk production. Blimp1 Prdm1 Transcriptional repressor Mammary gland morphogenesis Luminal progenitors Polarity Lumen formation 3D culture Mouse...

... cell formation. In order to gain further insight into the functional evolution of germ cell specification, here we examined the Gryllus ortholog of the transcription factor Blimp-1 (also known as Prdm1 ), which is a widely conserved bilaterian gene known to play a crucial role in the specification...

... ) Competing interests statement The authors declare no competing financial interests. 19 6 2013 © 2013. Published by The Company of Biologists Ltd 2013 Blimp1 Neural crest Neural plate border Prdm1 Neural crest cells (NCCs) are a transient population of stem cell-like...

... with differing requirements for Hedgehog and Prdm1 activity . Development 135 , 2115 - 2126 . Hagiwara N. , Ma B. , Ly A. ( 2005 ). Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H . Dev. Dyn. 234 , 301 - 311...

... ( myf6 ) myod myf5 Myogenin Hedgehog prdm1 pax3 meox1 hsp90 mef2d Motility is a key determinant of evolutionary success. During vertebrate evolution, somitic, appendicular and head muscle has undergone significant adaptation as fish evolved and moved onto land. One major...

... show here that different subsets of these slow fibres express distinct members of a tandem array of slow MyHC genes. The first slow twitch muscle fibres to differentiate, which are specified by the activity of the transcription factor Prdm1 (also called Ubo or Blimp1) in response to Hedgehog (Hh...

... Myosin Muscle Zebrafish Myofibril Somite tnnc Myogenin Hoover prdm1 eng2a acta1 actc1 smyhc1 myhz1 tpma mybpc1 hsp90a Skeletal myogenesis involves three steps: (1) commitment of proliferative mesodermal cells as myoblasts, (2) terminal differentiation, often...

... regulatory hierarchy has not been determined in any species. tbx5 is the earliest gene expressed in the limb bud mesenchyme. Recently, another transcription factor, Prdm1, has been shown to be crucial for zebrafish forelimb development. Here, we show that Prdm1 is downstream of RA, Wnt2b and Tbx5 activity...