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Keywords: Pou2
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Journal Articles
Journal: Development
Development (2006) 133 (14): 2757–2770.
Published: 15 July 2006
... dorsally located organizer. This interplay generates a zygotic Bmp activity gradient that defines distinct positional values along the DV axis. The maternal processes that control expression of the zygotic genes implicated in DV patterning are largely unknown. spiel-ohne-grenzen ( spg/pou2 ) is a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (10): 1881–1890.
Published: 15 May 2006
... pluripotent state. To our knowledge, few genes exhibit such a restricted expression to the central blastomeres. One of these is the zebrafish pou2 gene( Hauptmann and Gerster, 1995 ; Takeda et al., 1994 ), which is related to the mammalian transcription factor Pou5f1 (formally Oct3/4 ) ( Okamoto et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (4): 905–916.
Published: 15 February 2002
... causes a similar phenotype, but for which the affected gene is unknown. We show through genetic mapping, cloning of the proviral insertion site and allele sequencing that spg mutations disrupt pou2, a gene encoding the Pou2 transcription factor. Based on chromosomal synteny, phylogenetic sequence...
Journal Articles
Journal: Development
Development (2002) 129 (4): 917–933.
Published: 15 February 2002
.... Genetic mapping and molecular characterization presented in the accompanying paper revealed that spg mutations disrupt the pou2 gene, which encodes a POU domain transcription factor that is specifically expressed in the MHB primordium, and is orthologous to mammalian Oct3/Oct4. We show that embryos...