... as cardiac conduction disease. Moreover, using ST8sia2 and ST8sia4 knockout mice, we show that inhibition of post-translational modification of NCAM-1 by polysialic acid leads to disrupted trafficking of sarcolemmal intercalated disc proteins to junctional membranes and abnormal expansion...

...Xinghua Yin; Michiko Watanabe; Urs Rutishauser ABSTRACT We have demonstrated previously that the polysialic acid (PSA) moiety of the neural cell adhesion molecule (NCAM) can regulate peripheral nerve branching during development. In particular, it was found that specific enzymatic removal of PSA...

... responsiveness to NCAM and N-cadherin in the developing hippocampus. NCAM-dependent neurite outgrowth from E17 neurons was largely dependent on the presence of α2–8-linked polysialic acid (PSA) on neuronal NCAM. NCAM-dependent neurite outgrowth could be fully inhibited by pertussis toxin or a combination of L...

... © 1991 by Company of Biologists 1991 mouse embryo polysialic acid N-CAM endorieuramimdase spinal cord neural crest cells neural crest derivatives Informative interactions between cell surfaces are thought to be essential to the processes of cell recognition, sorting...