... epigenetically stable expression states. Chromatin Epigenetics Polycomb group Transcriptional memory Trithorax group Just as our understanding of personal identity is rooted in our memories, cellular identity is likewise grounded in transcriptional memory. It is essential for cells to remember...

... model for bivalency. In contrast, we propose that Mll2 is the pioneer trimethyltransferase for promoter definition in the naïve epigenome and that Polycomb group action on bivalent promoters blocks the premature establishment of active, Set1C-bound, promoters. ‡ Authors for correspondence...

...Kristel M. Dorighi; John W. Tamkun Members of the Polycomb group of repressors and trithorax group of activators maintain heritable states of transcription by modifying nucleosomal histones or remodeling chromatin. Although tremendous progress has been made toward defining the biochemical...

... that the epidermis dramatically attenuates MRC expression during ageing but restores gene activity when budding commences. During budding and ageing, the nuclear gene Eed (a polycomb group component) was activated and inactivated in a pattern similar to that observed in MRCs. In buds, RNA interference (RNAi) of Eed...

...Julia Engelhorn; Julia J. Reimer; Iris Leuz; Ulrike Göbel; Bruno Huettel; Sara Farrona; Franziska Turck In a reverse genetics screen based on a group of genes enriched for development-related Polycomb group targets in the apex (DPAs), we isolated DPA4 as a novel regulator of leaf margin shape. T...

... properties of Polycomb-group proteins, whereas their activities are generally opposed by the trithorax group. Both groups modify chromatin structure, but how their opposing activities are targeted to allow differential maintenance remains a mystery. Here, we identify a strong pairing-sensitive silencing (PSS...

...Bruno Bello; Niklaus Holbro; Heinrich Reichert Genes of the Polycomb group (PcG) are part of a cellular memory system that maintains appropriate inactive states of Hox gene expression in Drosophila . Here, we investigate the role of PcG genes in postembryonic development of the Drosophila CNS. We...

...Jian Wang; Ching-Hsien J. Lee; Suewei Lin; Tzumin Lee Polyhomeotic (Ph), which forms complexes with other Polycomb-group (PcG)proteins, is widely required for maintenance of cell identity by ensuring differential gene expression patterns in distinct types of cells. Genetic mosaic screens in adult...

...-mail: [email protected] ) * Present address: Institut für Biologie, Genetik, Freie Universität Berlin, 14195 Berlin, Germany 2 6 2005 ©2005. 2005 Transdetermination Cellular plasticity Imaginal disc Polycomb group Trithorax group Expression profiling...

...Karine Narbonne; Florence Besse; Jeanine Brissard-Zahraoui; Anne-Marie Pret; Denise Busson The polyhomeotic ( ph ) gene of Drosophila is a member of the Polycomb group ( Pc -G) genes, which are required for maintenance of a repressed state of homeotic gene transcription, which stabilizes cell...

... activities of Zeste and GAGA are an essential component of the mechanism that chooses which maintenance system is to be targeted to a given promoter. *Author for correspondence (e-mail: [email protected] ) 17 12 2001 © 2002. 2002 Polycomb group Trithorax group Homeotic Zeste GAGA...

...Anna Birve; Aditya K. Sengupta; Dirk Beuchle; Jan Larsson; James A. Kennison; Åsa Rasmuson-Lestander; Jürg Müller In both Drosophila and vertebrates, spatially restricted expression of HOX genes is controlled by the Polycomb group (PcG) repressors. Here we characterize a novel Drosophila PcG...

... remain off in all the descendent cells, even though the Gap repressors are no longer present. This phenomenon of heritable silencing depends on proteins of the Polycomb Group (PcG) and on cis -acting Polycomb response elements (PREs) in the Hox gene loci. We have removed individual PcG proteins from...

.... * Author for correspondence (e-mail: [email protected] ) 28 12 1998 15 02 1999 © 1999 by Company of Biologists 1999 Polycomb group Trithorax group Transcription Chromatin Homeotic BRM Drosophila kismet The homeotic genes of the Antennapedia (ANTC...

...Kryn Stankunas; Joel Berger; Chris Ruse; Donald A. R. Sinclair; Filippo Randazzo; Hugh W. Brock ABSTRACT The Polycomb group of genes in Drosophila are homeotic switch gene regulators that maintain homeotic gene repression through a possible chromatin regulatory mechanism. The Enhancer of Polycomb...

...Feng Tie; Takehito Furuyama; Peter J. Harte ABSTRACT The Polycomb Group gene esc encodes an evolutionarily conserved protein required for transcriptional silencing of the homeotic genes. Unlike other Polycomb Group genes, esc is expressed and apparently required only during early embryogenesis...

... and mes-6 . The proteins encoded by mes-2 and mes-6 have been shown to be related to the Polycomb Group of transcriptional repressors (Holdeman, R., Nehrt, S. and Strome, S. (1998). Development 125, 2457-2467; Korf, I., Fan, F. and Strome, S. (1998). Development 125, 2469-2478). These results suggest...

... similar to the Drosophila Polycomb group protein, Enhancer of zeste, and in the accompanying paper that mes-6 encodes another Polycomb group protein. The Polycomb group is responsible for maintaining proper patterns of expression of the homeotic and other genes in Drosophila . It is thought that Polycomb...

...-6 gene is in an unusual operon, the second example of this type of operon in C. elegans , and encodes the nematode homolog of Extra sex combs, a WD-40 protein in the Polycomb group in Drosophila. mes-2 encodes another Polycomb group protein (see paper by Holdeman, R., Nehrt, S. and Strome, S. (1998...

...Donald A. R. Sinclair; Thomas A. Milne; Jacob W. Hodgson; Joan Shellard; Claudia A. Salinas; Michael Kyba; Filippo Randazzo; Hugh W. Brock ABSTRACT The Additional sex combs ( Asx) gene of Drosophila is a member of the Polycomb group of genes, which are required for maintenance of stable repression...