... be redirected when discs regenerate after injury or when key selector genes are misregulated. Here, we show that when Polycomb expression is reduced, the wing selector gene vestigial is ectopically activated. This leads to the inappropriate formation of the Vestigial–Scalloped complex, which forces the eye...

... , A. and Klose , R. J. ( 2020 ). PRC1 catalytic activity is central to polycomb system function . Mol. Cell 77 , 857 - 874.e9. 10.1016/j.molcel.2019.12.001 Bonaccorsi , S. , Pisano , C. , Puoti , F. and Gatti , M. ( 1988 ). Y chromosome loops in Drosophila melanogaster...

...Anna L. F. V. Assumpção; Guoping Fu; Deependra K. Singh; Zhanping Lu; Ashley M. Kuehnl; Rene Welch; Irene M. Ong; Renren Wen; Xuan Pan ABSTRACT Yin Yang 1 (YY1) is a ubiquitous transcription factor and mammalian Polycomb Group protein (PcG) with important functions for regulating lymphocyte...

... the ability of Xist to recruit polycomb complex activity. We performed immunofluorescence staining with antisera specific for Ezh2, H3K27me3 and H2AK119ub in combination with Xist RNA fluorescent in situ hybridisation (FISH) after 24 h of Xist induction ( Fig. 3 , Fig. S3 ). We counted the number...

... required for altering lineage patterns in type II neuroblasts (NBs), one of the two main Drosophila NSC identities. Finally, we demonstrate that this subtype specification in NBs, unlike NSC differentiation, requires Polycomb-group-mediated repression. * Present address: Netherlands Cancer Institute...

...Julien Rougeot; Naomi D. Chrispijn; Marco Aben; Dei M. Elurbe; Karolina M. Andralojc; Patrick J. Murphy; Pascal W. T. C. Jansen; Michiel Vermeulen; Bradley R. Cairns; Leonie M. Kamminga ABSTRACT Polycomb group (PcG) proteins are transcriptional repressors that are important regulators of cell fate...

...Jumana Alhaj Abed; Elnaz Ghotbi; Piao Ye; Alexander Frolov; Judith Benes; Richard S. Jones ABSTRACT Polycomb-group (PcG)-mediated transcriptional repression of target genes can be delineated into two phases. First, following initial repression of target genes by gene-specific transcription factors...

...-distal (PD) specification of the forelimb. Polycomb group (PcG) factors play a role in downregulation of retinoic acid (RA)-related signals in the distal forelimb bud, causing Meis repression. It is, however, not known whether downregulation of RA-related signals and PcG-mediated proximal gene repression...

... urchins and frogs. Here, we demonstrate that Polycomb group (PcG) proteins maintain Drosophila eye specification by suppressing the activation of alternative fate choices. The loss of PcG in the developing eye results in a cellular reprogramming event in which the eye is redirected to a wing fate...

...Anne Grijzenhout; Jonathan Godwin; Haruhiko Koseki; Michal Ryszard Gdula; Dorota Szumska; Joanna F. McGouran; Shoumo Bhattacharya; Benedikt M. Kessler; Neil Brockdorff; Sarah Cooper The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular...

... of Biologists Ltd 2016 Summary: Cerebellar deletion of Ezh2 leads to increased GABAergic interneurons, decreased Purkinje cells and blocked proliferation of granule precursor cells derived from the rhombic lip. Polycomb Ezh2 PRC2 Cerebellum Neurogenesis Purkinje cells During neural...

... cell type. Of these, rod and cone photoreceptors represent the functional unit of light detection and phototransduction and are frequently affected in retinal degenerative diseases. During mouse development, the Polycomb group protein Bmi1 is expressed in immature retinal progenitors and differentiated...

...Nayuta Yakushiji-Kaminatsui; Takashi Kondo; Takaho A. Endo; Yoko Koseki; Kaori Kondo; Osamu Ohara; Miguel Vidal; Haruhiko Koseki Polycomb group (PcG) proteins play a pivotal role in silencing developmental genes and help to maintain various stem and precursor cells and regulate...

... during leg regeneration in cricket leads to defects in proximodistal patterning of the regenerating limb. Regeneration Epigenetics Histone H3K27 Gryllus bimaculatus Polycomb Regeneration is a phenomenon in which animals restore lost tissue parts using remaining cells. This phenomenon...

... is essential for determining the number of neurons of each subtype and for precisely generating the cortical layer structure, the molecular mechanisms underlying these switches are largely unknown. Here, we show that epigenetic regulation through Ring1B, an essential component of polycomb group (PcG) complex...

... for hit identification. Candidate factors identified were enriched for transcription factors and included known Polycomb proteins and other chromatin-modifying factors. We identified the protein Bcor, which is known to associate in complexes with the Polycomb protein Ring1B, and verified its importance...

...Ömer Copur; Jürg Müller Trimethylation of histone H3 at lysine 27 (H3-K27me3) by Polycomb repressive complex 2 (PRC2) is a key step for transcriptional repression by the Polycomb system. Demethylation of H3-K27me3 by Utx and/or its paralogs has consequently been proposed to be important...

...Luigi Aloia; Bruno Di Stefano; Luciano Di Croce Polycomb group (PcG) proteins are epigenetic modifiers involved in controlling gene repression. Organized within multiprotein complexes, they regulate developmental genes in multiple cell types and tissue contexts, including embryonic and adult stem...

.... Here, we demonstrate that Cbx4, a Polycomb protein that is highly expressed in the thymic epithelium, has an essential and non-redundant role in thymic organogenesis. Targeted disruption of Cbx4 causes severe hypoplasia of the fetal thymus as a result of reduced thymocyte proliferation. Cell-specific...

... ( wapl AG ) in a screen for mutations that counteract silencing mediated by an engrailed Polycomb-group response element. wapl AG hemizygotes die as pharate adults and have an extra sex combs phenotype characteristic of males with mutations in Polycomb-group (PcG) genes. The wapl gene encodes two...