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Keywords: Polycomb
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Journal Articles
Journal: Development
Development (2023) 150 (18): dev201872.
Published: 25 September 2023
... be redirected when discs regenerate after injury or when key selector genes are misregulated. Here, we show that when Polycomb expression is reduced, the wing selector gene vestigial is ectopically activated. This leads to the inappropriate formation of the Vestigial–Scalloped complex, which forces the eye...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2023) 150 (14): dev201557.
Published: 19 July 2023
... , A. and Klose , R. J. ( 2020 ). PRC1 catalytic activity is central to polycomb system function . Mol. Cell 77 , 857 - 874.e9. 10.1016/j.molcel.2019.12.001 Bonaccorsi , S. , Pisano , C. , Puoti , F. and Gatti , M. ( 1988 ). Y chromosome loops in Drosophila melanogaster...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev197319.
Published: 15 April 2021
...Anna L. F. V. Assumpção; Guoping Fu; Deependra K. Singh; Zhanping Lu; Ashley M. Kuehnl; Rene Welch; Irene M. Ong; Renren Wen; Xuan Pan ABSTRACT Yin Yang 1 (YY1) is a ubiquitous transcription factor and mammalian Polycomb Group protein (PcG) with important functions for regulating lymphocyte...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175141.
Published: 11 June 2020
... that requires A repeat sequences of Xist RNA, as well as the RNA-binding protein Spen ( Chu et al., 2015 ; McHugh et al., 2015 ; Monfort et al., 2015 ; Wutz et al., 2002 ). The recruitment of polycomb proteins by Xist induces chromosome-wide histone modifications and this recruitment requires hnRNPK...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev183400.
Published: 2 December 2019
... required for altering lineage patterns in type II neuroblasts (NBs), one of the two main Drosophila NSC identities. Finally, we demonstrate that this subtype specification in NBs, unlike NSC differentiation, requires Polycomb-group-mediated repression. * Present address: Netherlands Cancer Institute...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (23): dev165027.
Published: 27 November 2018
...Jumana Alhaj Abed; Elnaz Ghotbi; Piao Ye; Alexander Frolov; Judith Benes; Richard S. Jones ABSTRACT Polycomb-group (PcG)-mediated transcriptional repression of target genes can be delineated into two phases. First, following initial repression of target genes by gene-specific transcription factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev166348.
Published: 11 October 2018
...-distal (PD) specification of the forelimb. Polycomb group (PcG) factors play a role in downregulation of retinoic acid (RA)-related signals in the distal forelimb bud, causing Meis repression. It is, however, not known whether downregulation of RA-related signals and PcG-mediated proximal gene repression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev160754.
Published: 4 April 2018
... urchins and frogs. Here, we demonstrate that Polycomb group (PcG) proteins maintain Drosophila eye specification by suppressing the activation of alternative fate choices. The loss of PcG in the developing eye results in a cellular reprogramming event in which the eye is redirected to a wing fate...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (11): 1971–1980.
Published: 1 June 2016
... of Biologists Ltd 2016 Summary: Cerebellar deletion of Ezh2 leads to increased GABAergic interneurons, decreased Purkinje cells and blocked proliferation of granule precursor cells derived from the rhombic lip. Polycomb Ezh2 PRC2 Cerebellum Neurogenesis Purkinje cells During neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1571–1584.
Published: 1 May 2016
... cell type. Of these, rod and cone photoreceptors represent the functional unit of light detection and phototransduction and are frequently affected in retinal degenerative diseases. During mouse development, the Polycomb group protein Bmi1 is expressed in immature retinal progenitors and differentiated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 276–285.
Published: 15 January 2016
...Nayuta Yakushiji-Kaminatsui; Takashi Kondo; Takaho A. Endo; Yoko Koseki; Kaori Kondo; Osamu Ohara; Miguel Vidal; Haruhiko Koseki Polycomb group (PcG) proteins play a pivotal role in silencing developmental genes and help to maintain various stem and precursor cells and regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2916–2927.
Published: 1 September 2015
... during leg regeneration in cricket leads to defects in proximodistal patterning of the regenerating limb. Regeneration Epigenetics Histone H3K27 Gryllus bimaculatus Polycomb Regeneration is a phenomenon in which animals restore lost tissue parts using remaining cells. This phenomenon...
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Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (19): 4110–4115.
Published: 1 October 2013
... for hit identification. Candidate factors identified were enriched for transcription factors and included known Polycomb proteins and other chromatin-modifying factors. We identified the protein Bcor, which is known to associate in complexes with the Polycomb protein Ring1B, and verified its importance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3478–3485.
Published: 15 August 2013
...Ömer Copur; Jürg Müller Trimethylation of histone H3 at lysine 27 (H3-K27me3) by Polycomb repressive complex 2 (PRC2) is a key step for transcriptional repression by the Polycomb system. Demethylation of H3-K27me3 by Utx and/or its paralogs has consequently been proposed to be important...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2525–2534.
Published: 15 June 2013
...Luigi Aloia; Bruno Di Stefano; Luciano Di Croce Polycomb group (PcG) proteins are epigenetic modifiers involved in controlling gene repression. Organized within multiprotein complexes, they regulate developmental genes in multiple cell types and tissue contexts, including embryonic and adult stem...
Journal Articles
Journal: Development
Development (2013) 140 (4): 780–788.
Published: 15 February 2013
.... Here, we demonstrate that Cbx4, a Polycomb protein that is highly expressed in the thymic epithelium, has an essential and non-redundant role in thymic organogenesis. Targeted disruption of Cbx4 causes severe hypoplasia of the fetal thymus as a result of reduced thymocyte proliferation. Cell-specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4172–4179.
Published: 15 November 2012
... ( wapl AG ) in a screen for mutations that counteract silencing mediated by an engrailed Polycomb-group response element. wapl AG hemizygotes die as pharate adults and have an extra sex combs phenotype characteristic of males with mutations in Polycomb-group (PcG) genes. The wapl gene encodes two...
Includes: Supplementary data