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Keywords: Pluripotent stem cells
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Human development
Journal: Development
Development (2023) 150 (19): dev201871.
Published: 5 October 2023
... lineages. Although we have learned much from animal models, many details about human inner ear development remain elusive. We recently developed an in vitro model of human inner ear organogenesis using pluripotent stem cells in a 3D culture, fostering the growth of a sensorineural circuit, including hair...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (14): dev201509.
Published: 13 July 2023
...Olga G. Jaime; Jessica Arias; Shreya Pavani; April D. Pyle; Michael R. Hicks ABSTRACT The earliest skeletal muscle progenitor cells (SMPCs) derived from human pluripotent stem cells (hPSCs) are often identified by factors expressed by a diverse number of progenitors. An early transcriptional...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201120.
Published: 1 November 2022
... interactions Human development Disease modeling Pluripotent stem cells European Molecular Biology Organization http://dx.doi.org/10.13039/100004410 ALTF 321-2021 Wu Tsai Neurosciences Institute, Stanford University Stanford Bio-X New York Stem Cell Foundation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev200561.
Published: 5 September 2022
...Daniel Medina-Cano; Emily K. Corrigan; Rachel A. Glenn; Mohammed T. Islam; Yuan Lin; Juliet Kim; Hyunwoo Cho; Thomas Vierbuchen ABSTRACT Directed differentiation of pluripotent stem cells (PSCs) is a powerful model system for deconstructing embryonic development. Although mice are the most advanced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200226.
Published: 23 June 2022
... analysis tools. Here, we introduce SyNPL: clonal pluripotent stem cell lines that employ optimised Synthetic Notch (SynNotch) technology to report cell-cell interactions between engineered ‘sender’ and ‘receiver’ cells in cultured pluripotent cells and chimaeric mouse embryos. A modular design makes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199732.
Published: 19 October 2021
... and human embryonic stem cells . Cell Stem Cell 6 , 215 - 226 . 10.1016/j.stem.2010.01.003 Hayashi , K. , Ohta , H. , Kurimoto , K. , Aramaki , S. and Saitou , M. ( 2011 ). Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells...
Includes: Supplementary data
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Journal: Development
Development (2021) 148 (4): dev180612.
Published: 16 February 2021
... and regenerative medicine. Axis elongation Gastrulation Neuromesodermal progenitors Primitive streak Tail bud Pluripotent stem cells Lineage specification in the early vertebrate embryo is initiated during gastrulation (see Glossary, Box 1 ), which involves the formation of the three germ...
Journal Articles
Journal: Development
Development (2020) 147 (18): dev192567.
Published: 17 September 2020
...Hideyuki Okano; Doug Sipp ABSTRACT Regenerative therapies, including both gene and cellular therapies, aim to induce regeneration of cells, tissues and organs and restore their functions. In this short Spotlight, we summarize the latest advances in cellular therapies using pluripotent stem cells...
Journal Articles
Journal: Development
Development (2020) 147 (1): dev183095.
Published: 3 January 2020
... governing ethical considerations of human embryonic research have allowed us to enlighten this black box. Here, we will summarize the current knowledge of human XCI, mainly based on the analyses of embryos derived from in vitro fertilization and of pluripotent stem cells, and highlight any unanswered...
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Journal: Development
Development (2017) 144 (15): 2748–2763.
Published: 1 August 2017
...Ge Guo; Ferdinand von Meyenn; Maria Rostovskaya; James Clarke; Sabine Dietmann; Duncan Baker; Anna Sahakyan; Samuel Myers; Paul Bertone; Wolf Reik; Kathrin Plath; Austin Smith Much attention has focussed on the conversion of human pluripotent stem cells (PSCs) to a more naïve developmental status...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2104–2122.
Published: 15 June 2017
... basis of skeletal muscle diseases, but also provide a roadmap for recapitulating skeletal myogenesis in vitro from pluripotent stem cells (PSCs). PSCs have become an important tool for probing developmental questions, while differentiated cell types allow the development of novel therapeutic strategies...
Includes: Supplementary data
Journal Articles