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Keywords: Pluripotent stem cell
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Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (12): dev195792.
Published: 16 June 2021
... gene function in development, involves injecting donor pluripotent stem cells into an organogenesis-disabled host embryo, allowing the donor cells to compensate for missing organs or tissues. Although interspecies blastocyst complementation has been achieved between closely related species...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev187344.
Published: 26 June 2020
... + myogenic precursors set aside during development. Although myogenesis has been studied in mouse and chicken embryos, little is known about human muscle development. Here, we report the generation of human induced pluripotent stem cell (iPSC) reporter lines in which fluorescent proteins have been introduced...
Includes: Supplementary data
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Journal: Development
Development (2017) 144 (14): 2544–2547.
Published: 15 July 2017
... by The Company of Biologists Ltd 2017 Summary: This Spotlight discusses the potential of interspecies chimeras for human stem cell research but also the significant barriers and ethical issues surrounding their generation. Pluripotent stem cell Interspecies chimera Heterochronicity Chimeric...
Journal Articles
Journal: Development
Development (2017) 144 (14): 2544–2547.
Published: 15 July 2017
... by The Company of Biologists Ltd 2017 Summary: This Spotlight discusses the potential of interspecies chimeras for human stem cell research but also the significant barriers and ethical issues surrounding their generation. Pluripotent stem cell Interspecies chimera Heterochronicity Chimeric...
Journal Articles
Journal: Development
Development (2017) 144 (9): 1584–1587.
Published: 1 May 2017
...J. Gray Camp; Barbara Treutlein Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these ‘organoids’ into constituent...
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (11): 1937–1947.
Published: 1 June 2015
... (MM), which forms the rest of the kidney, derive from the IM. Based on an understanding of the signalling molecules crucial for IM patterning and kidney morphogenesis, several studies have now generated UB or MM, or both, in vitro via the directed differentiation of human pluripotent stem cells...
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Journal: Development
Development (2010) 137 (14): 2279–2287.
Published: 15 July 2010
... synthase kinase 3. The inhibitors suppress differentiation and enable self-renewal of pluripotent cells that are ex vivo counterparts of naïve epiblast cells in the mature blastocyst. Pluripotent stem cell lines can also be derived from unipotent primordial germ cells via a poorly understood process...
Includes: Multimedia, Supplementary data