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Keywords: Pluripotency Gene Regulatory Network
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Journal Articles
Luca Giovanni Di Giovannantonio, Dario Acampora, Daniela Omodei, Vincenzo Nigro, Pasquale Barba, Elisa Barbieri, Ian Chambers, Antonio Simeone
Journal:
Development
Development (2021) 148 (10): dev199166.
Published: 17 May 2021
... signaling. Entry into the germline requires activation of a naïve-like pluripotency gene regulatory network (GRN). Recent work has shown that suppression of OTX2 expression in the epiblast by BMP4 allows cells to develop a PGC fate in a precise temporal window. However, the mechanisms by which OTX2...
Includes: Supplementary data
