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Keywords: Pluripotency
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Journal Articles
Journal: Development
Development (2022) 149 (20): dev200679.
Published: 14 September 2022
... oxygen tension) induces WNT pathway activity and is harnessed to enhance differentiation of embryonic stem cells into gastruloids. Hypoxia Hif1a WNT Gastruloid Pluripotency Max-Planck-Gesellschaft Bundesinstitut für Risikobewertung http://dx.doi.org/10.13039/501100008751...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200361.
Published: 22 April 2022
... and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo reprogramming are a promising strategy for tissue regeneration and rejuvenation. However, little is known about the barriers that impair reprogramming...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev199901.
Published: 7 December 2021
... ABSTRACT Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the embryo uncertain. Here, we avoided using feeder...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199909.
Published: 28 October 2021
... and function, microtubules have received less attention when unravelling the regulatory circuitry of pluripotency. Here, we summarise the role of microtubule organisation and microtubule-dependent events required for the formation of pluripotent cells in vivo by deciphering the process of early embryogenesis...
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199604.
Published: 10 September 2021
...Nicola Festuccia; Nick Owens; Almira Chervova; Agnès Dubois; Pablo Navarro ABSTRACT The maintenance of pluripotency in mouse embryonic stem cells (ESCs) is governed by the action of an interconnected network of transcription factors. Among them, only Oct4 and Sox2 have been shown to be strictly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev189217.
Published: 15 March 2021
... pluripotent stem cells (iPSCs) uses either aggregate models or embryo models. (A) Aggregate models involve the generation of disorganized three-dimensional aggregates with primordial germ cell (PGC)-like cells (PGCLCs) induced from either a progenitor intermediate or by direct induction in response to BMP4...
Journal Articles
Journal: Development
Development (2020) 147 (16): dev189845.
Published: 26 August 2020
..., they are referred to as pluripotent, rather than totipotent. Here, we consider the experimental potential of various ESC populations and a number of recently identified in vitro culture systems producing states beyond pluripotency and reminiscent of those observed during pre-implantation development. We also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (16): dev185264.
Published: 24 August 2020
...Zhenhua Zhu; Yan Zhang; Xiaoxiao Wang; Xiaohu Wang; Shou-Dong Ye ABSTRACT The identification of novel mechanisms to maintain embryonic stem cell (ESC) pluripotency is of crucial importance, because the currently used culture conditions are not suitable for ESCs from all species. In this study, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev184960.
Published: 3 February 2020
...Sofiane Hamidi; Yukiko Nakaya; Hiroki Nagai; Cantas Alev; Takeya Kasukawa; Sapna Chhabra; Ruda Lee; Hitoshi Niwa; Aryeh Warmflash; Tatsuo Shibata; Guojun Sheng ABSTRACT The pluripotent epiblast gives rise to all tissues and organs in the adult body. Its differentiation starts at gastrulation, when...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev183129.
Published: 15 January 2020
... development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and non-catalytic activities of TETs, and their roles as epigenetic regulators of both...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev174516.
Published: 10 October 2019
... Pluripotency Heterochromatin Embryogenesis met-2 Upon fertilization, embryos initiate developmental events to control cell division, pluripotency, differentiation, reorganization of the nucleus, onset of transcription and repositioning of cells into germ layers that ultimately generate organs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev164772.
Published: 25 September 2019
...Deniz Gökbuget; Robert Blelloch ABSTRACT Pluripotent stem cells give rise to all cells of the adult organism, making them an invaluable tool in regenerative medicine. In response to differentiation cues, they can activate markedly distinct lineage-specific gene networks while turning off...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev174722.
Published: 12 September 2019
...Alexander M. Tsankov; Marc H. Wadsworth, II; Veronika Akopian; Jocelyn Charlton; Samuel J. Allon; Aleksandra Arczewska; Benjamin E. Mead; Riley S. Drake; Zachary D. Smith; Tarjei S. Mikkelsen; Alex K. Shalek; Alexander Meissner ABSTRACT Maintenance of pluripotency and specification towards a new...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev177220.
Published: 21 June 2019
..., and how CRISPR/Cas9 modified iPSCs grown into organoids can be used to study these deletion effects. Whether pluripotent stem cells in culture reflect the pre-implantation (naïve) state or the post-implantation (primed) state of the early embryo has been a matter of discussion over the years...
Journal Articles
Journal: Development
Development (2019) 146 (10): dev173112.
Published: 22 May 2019
.... and Jaynes , J. B. ( 1996 ). A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivo . Development   122 , 3141 - 3150 . Sokol , S. Y. ( 2011 ). Maintaining embryonic stem cell pluripotency...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev173146.
Published: 26 March 2019
... differentiation ( Fig. 6 A). If starting from 2i+LIF or if cells have to be pre-plated before initiating differentiation, there will be more proliferation before exiting pluripotency. Cell density can be lowered to 0.8×10 4 cells/cm 2 . The efficiency and timing of differentiation can be assessed by using...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev167833.
Published: 9 November 2018
... expression signatures are species, stage and lineage specific. The pluripotency network in the primate epiblast lacks certain regulators that are operative in mouse, but encompasses WNT components and genes associated with trophoblast specification. Sequential activation of GATA6, SOX17 and GATA4 markers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163386.
Published: 8 August 2018
... for HDAC activity initiates in naïve blastula cells; HDAC inhibition causes loss of pluripotency gene expression and blocks the ability of blastula stem cells to contribute to lineages of the three embryonic germ layers. We find that pluripotent naïve blastula cells and neural crest cells are both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev159103.
Published: 18 June 2018
... of the presumptive endodermal domain and trapping of cells in the primitive streak ultimately result in consistent disrupted phenotype with loss of embryonic structures. Oct4 Epiblast Lineage specification Gastrulation Pluripotency Embryonic axis * Present address: Bioprocessing Technology...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev163501.
Published: 8 June 2018
.... Here, we summarise key findings from this meeting, which brought together emerging leaders to discuss various topics, including pluripotency, organoids, endogenous regeneration, transcriptional regulation, clinical applications and emerging technologies. Much like the classical compositions...