... on the axon guidance regulator Plexin A. In Plexin A null mutants, synaptic layers of the medulla neuropil and arborizations of individual neurons are wider and less distinct than in controls. Analysis of semaphorin function indicates that Semaphorin 1a, acting in a subset of medulla neurons, is the primary...

... for neuroendocrine neurons to migrate into the hypothalamus and release gonadotropins into the circulation. GnRH neuron Olfactory bulb Testes Axon guidance Plexin Semaphorin Hypogonadotropic hypogonadism Kallmann syndrome GnRH-secreting neurons are hypothalamic neuroendocrine cells that regulate...

... functional activity of semaphorin 3B is required for positioning the anterior commissure . Neuron 48, 63-75 . 10.1016/j.neuron.2005.10.024 Fujisawa H. ( 2004 ). Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development . J. Neurobiol. 59 , 24...

... within a tissue domain. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing financial interests. 3 10 2013 24 4 2014 © 2014. Published by The Company of Biologists Ltd 2014 Plexin Semaphorin Morphogenesis...

... Xenopus Plexin Neurons are polarized structures, generally with a single, long axon and an arbor of short, branched dendrites, present on opposite sides of the cell. Polarization is crucial for neuronal function and is necessary for the emergence of working networks in the brain. How a neuron...

... for correspondence ( [email protected] ) * These authors contributed equally to this work Competing interests statement The authors declare no competing financial interests. 29 6 2011 © 2011. Semaphorin Plexin Spinal cord Synapse formation Oligodendrocyte...

... of neuropilin 1 (Npn1) inhibits cleft formation in the developing submandibular gland (SMG) cultured ex vivo. This Npn1-dependent morphogenesis is mediated by Sema3A and Sema3C in an additive manner, and can be abolished by decreasing the expression of plexin A2 or plexin D1. VEGF, another known Npn1 ligand...

...Joseph C. Ayoob; Jonathan R. Terman; Alex L. Kolodkin Plexin receptors play a crucial role in the transduction of axonal guidance events elicited by semaphorin proteins. In Drosophila , Plexin A(PlexA) is a receptor for the transmembrane semaphorin semaphorin-1a (Sema-1a)and is required for motor...

...Takashi Fujii; Fumi Nakao; Yukimasa Shibata; Go Shioi; Eiji Kodama; Hajime Fujisawa; Shin Takagi The plexin family transmembrane proteins are putative receptors for semaphorins, which are implicated in the morphogenesis of animal embryos, including axonal guidance. We have generated...

... to demonstrate that PlexinA2 is expressed by migrating and postmigratory cardiac neural crest cells in the mouse. Plexins function as co-receptors for semaphorin signaling molecules and mediate axon pathfinding in the central nervous system. We demonstrate that PlexinA2 -expressing cardiac neural crest cells...