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Keywords: Plexin
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Neural development
Journal: Development
Development (2024) 151 (10): dev202237.
Published: 22 May 2024
... on the axon guidance regulator Plexin A. In Plexin A null mutants, synaptic layers of the medulla neuropil and arborizations of individual neurons are wider and less distinct than in controls. Analysis of semaphorin function indicates that Semaphorin 1a, acting in a subset of medulla neurons, is the primary...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (21): dev176461.
Published: 5 November 2019
... for neuroendocrine neurons to migrate into the hypothalamus and release gonadotropins into the circulation. GnRH neuron Olfactory bulb Testes Axon guidance Plexin Semaphorin Hypogonadotropic hypogonadism Kallmann syndrome GnRH-secreting neurons are hypothalamic neuroendocrine cells that regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3292–3297.
Published: 1 September 2014
... and developmental processes, highlighting the mechanisms that act to fine-tune, diversify and spatiotemporally control the effects of semaphorins. In addition to being expressed in separate cells and acting in trans , semaphorins and plexins also engage in cis interactions, and three different modes...
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (14): 2933–2941.
Published: 15 July 2013
... Plexin Neurons are polarized structures, generally with a single, long axon and an arbor of short, branched dendrites, present on opposite sides of the cell. Polarization is crucial for neuronal function and is necessary for the emergence of working networks in the brain. How a neuron acquires...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2007) 134 (16): 2935–2945.
Published: 15 August 2007
... of neuropilin 1 (Npn1) inhibits cleft formation in the developing submandibular gland (SMG) cultured ex vivo. This Npn1-dependent morphogenesis is mediated by Sema3A and Sema3C in an additive manner, and can be abolished by decreasing the expression of plexin A2 or plexin D1. VEGF, another known Npn1 ligand...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (11): 2125–2135.
Published: 1 June 2006
...Joseph C. Ayoob; Jonathan R. Terman; Alex L. Kolodkin Plexin receptors play a crucial role in the transduction of axonal guidance events elicited by semaphorin proteins. In Drosophila , Plexin A(PlexA) is a receptor for the transmembrane semaphorin semaphorin-1a (Sema-1a)and is required for motor...
Journal Articles
Journal: Development
Development (2002) 129 (9): 2053–2063.
Published: 1 May 2002
...Takashi Fujii; Fumi Nakao; Yukimasa Shibata; Go Shioi; Eiji Kodama; Hajime Fujisawa; Shin Takagi The plexin family transmembrane proteins are putative receptors for semaphorins, which are implicated in the morphogenesis of animal embryos, including axonal guidance. We have generated...
Journal Articles
Journal: Development
Development (2001) 128 (16): 3071–3080.
Published: 15 August 2001
... to demonstrate that PlexinA2 is expressed by migrating and postmigratory cardiac neural crest cells in the mouse. Plexins function as co-receptors for semaphorin signaling molecules and mediate axon pathfinding in the central nervous system. We demonstrate that PlexinA2 -expressing cardiac neural crest cells...