.... and Zallen , J. A. ( 2019 ). An LRR receptor-teneurin system directs planar polarity at compartment boundaries . Dev. Cell 51 , 208 - 221.e206 . 10.1016/j.devcel.2019.08.003 Proag , A. , Monier , B. and Suzanne , M. ( 2019 ). Physical and functional cell-matrix uncoupling...

...Su Ee Tan; Weijie Tan; Katherine H. Fisher; David Strutt ABSTRACT The coordination of cells or structures within the plane of a tissue is known as planar polarization. It is often governed by the asymmetric distribution of planar polarity proteins within cells. A number of quantitative methods have...

...-avoidance by regulating cytoskeletal assembly in the dendrite. Actin C. elegans Dendrite Flamingo Planar polarity Self-avoidance Dendrite self-avoidance prevents crossover between sister dendrites from the same neuron, maximizing coverage of the sensory territory of individual dendrites...

...Katherine H. Fisher; David Strutt ABSTRACT Planar polarity is a widespread phenomenon found in many tissues, allowing cells to coordinate morphogenetic movements and function. A common feature of animal planar polarity systems is the formation of molecular bridges between cells, which become...

...-licence-1-1/ Summary: The C. elegans cell polarity protein VANG-1 tempers Wnt-mediated neuronal migration by recycling Frizzled receptors from the neuronal membrane. C. elegans Wnt signaling Planar polarity Neuronal migration Endocytosis Frizzled Wiring of the nervous...

...), the Par-3 homologue, along the boundary cell-cell contacts. Moreover, Wingless and Hedgehog signalling have opposite effects on fold depth at the boundary that correlate with changes in Baz planar polarity. * These authors contributed equally to this work ‡ Author for correspondence ( bs251...

..., and provides a full suite of tools that allow users with no prior computational expertise to independently perform all steps of automated image segmentation, semi-automated user-guided error correction, and data analysis. Here we use SEGGA to analyze changes in cell shape, cell interactions and planar polarity...

... , N. , Strutt , D. I. and Mlodzik , M. ( 1998 ). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling . Cell   94 , 109 - 118 . 10.1016/S0092-8674(00)81226-X Brooks , S. P. , Coccia , M. , Tang , H. R. , Kanuga...

... , K. , Charroux , B. , Kerridge , S. and McNeill , H. ( 2003 ). The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor . Development   130 , 763 - 774 . 10.1242/dev.00304 Fuerst...

...Christian S. Kiefer; Andrea R. Claes; Jean-Claude Nzayisenga; Stefano Pietra; Thomas Stanislas; Anke Hüser; Yoshihisa Ikeda; Markus Grebe The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small...

...-Ft bridge formation between neighbouring cells, an event that then leads to loss of Dachs proximally and recruitment of Dachs distally. Such a mechanism might explain how this system can become planar polarized; however, it is still unclear how the system is able to read the slope of the Ds and Fj...

...Helen Strutt; Elizabeth Searle; Victoria Thomas-MacArthur; Rosalind Brookfield; David Strutt The asymmetric localisation of core planar polarity proteins at apicolateral junctions is required to specify cell polarity in the plane of epithelia. This asymmetric distribution of the core proteins...

..., cooperate to control PCP in the early mouse embryo. Two aspects of planar polarity can be analyzed quantitatively at cellular resolution in the mouse embryo: convergent extension of the axial midline; and posterior positioning of cilia on cells of the node. Analysis of the spatial distribution of brachyury...

... trafficking of E-cadherin (E-cad), but how this process can be polarised within individual cells is poorly understood. The Frizzled (Fz)-dependent core planar polarity pathway is a major regulator of polarised cell rearrangements in processes such as gastrulation, and has also been implicated in regulation...

...Emily Marcinkevicius; Jennifer A. Zallen The atypical cadherin Fat is a conserved regulator of planar cell polarity, but the mechanisms by which Fat controls cell shape and tissue structure are not well understood. Here, we show that Fat is required for the planar polarized organization of actin...

... Drosophila planar polarity patterning . Development 130 , 3007 - 3014 . Bonaglia M. C. , Marelli S. , Novara F. , Commodaro S. , Borgatti R. , Minardo G. , Memo L. , Mangold E. , Beri S. , Zucca C. , et al . ( 2010 ). Genotype-phenotype...

...Sakura Saburi; Ian Hester; Lisa Goodrich; Helen McNeill The atypical cadherin fat ( ft ) was originally discovered as a tumor suppressor in Drosophila and later shown to regulate a form of tissue patterning known as planar polarity. In mammals, four ft homologs have been identified ( Fat1 - 4...

...Lisa V. Goodrich; David Strutt Planar polarity describes the coordinated polarisation of cells or structures in the plane of a tissue. The patterning mechanisms that underlie planar polarity are well characterised in Drosophila , where many events are regulated by two pathways: the ‘core’ planar...

... polarization of their external sensory elements, called hair cells, for coherent information transfer. This organization allows animals to detect and interpret the direction of propagation of a sound. Because hair cells display their characteristic planar polarization only within an intact epithelium...

... R. A. , Lanford P. J. , Copeland N. G. , Jenkins N. A. , Kelley M. W. ( 2003 ). Identification of Vangl2 and Scrb1 as planar polarity genes in mammals . Nature 423 , 173 - 177 . Nishimura T. , Takeichi M. ( 2008 ). Shroom3-mediated recruitment of Rho...