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Keywords: Placenta
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Journal Articles
Journal: Development
Development (2024) 151 (2): dev202239.
Published: 17 January 2024
... specialized functions. Among the differentiated trophoblast cell lineages are invasive trophoblast cells, which exit the placenta and invade the uterus, where they restructure the uterine parenchyma and facilitate remodeling of uterine spiral arteries. The rat exhibits deep intrauterine trophoblast cell...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (11): dev201581.
Published: 6 June 2023
...Vijay Pratap Singh; Huzaifa Hassan; Fengyan Deng; Dai Tsuchiya; Sean McKinney; Kevin Ferro; Jennifer L. Gerton ABSTRACT The placenta is essential for reproductive success. The murine placenta includes polyploid giant cells that are crucial for its function. Polyploidy occurs broadly in nature...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (2): dev201095.
Published: 17 January 2023
... to exit the placenta and invade into the uterus where they restructure the vasculature. Invasive trophoblast cells arise from a well-defined compartment within the placenta, referred to as the junctional zone in rat and the extravillous trophoblast cell column in human. In this study, we investigated...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (23): dev201160.
Published: 5 December 2022
...Chang Cao; Mark D. Fleming ABSTRACT Fetal development relies on adequate iron supply by the placenta. The placental syncytiotrophoblasts (SCTB) express high levels of iron transporters, including ferroportin1 ( Fpn1 ). Whether they are essential in the placenta has not been tested directly, mainly...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (8): dev200104.
Published: 22 April 2022
...Laina Freyer; Yvan Lallemand; Pascal Dardenne; Alina Sommer; Anne Biton; Elisa Gomez Perdiguero ABSTRACT Hofbauer cells (HBCs) are tissue macrophages of the placenta thought to be important for fetoplacental vascular development and innate immune protection. The developmental origins of HBCs remain...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200013.
Published: 17 February 2022
.... ( 2014 ). The placenta harbors a unique microbiome . Sci. Transl. Med. 6 , 237ra65 . 10.1126/scitranslmed.3008599 Aghaeepour , N. , Ganio , E. A. , Mcilwain , D. , Tsai , A. S. , Tingle , M. , Van Gassen , S. , Gaudilliere , D. K. , Baca , Q. , McNeil , L...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199840.
Published: 12 January 2022
... is known about the processes controlling human CTB progenitor maintenance and differentiation. To address this, we established a single cell RNA sequencing (scRNA-seq) dataset from first trimester placentas to identify cell states important in trophoblast progenitor establishment, renewal...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (1): dev199811.
Published: 4 January 2022
... the importance of ICR1 in the placental production of hormones that promote maternal nutrient allocation to the fetus is unknown. To address this, we used a novel mouse model to selectively delete ICR1 in the endocrine junctional zone (Jz) of the mouse placenta (Jz-ΔICR1). The Jz-ΔICR1 mice exhibit increased...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (20): dev199626.
Published: 19 October 2021
... the uterine surface, these progenitors assume a different fate, becoming cancer-like cells that invade its lining and blood vessels. The latter process physically connects the placenta to the mother and shunts uterine blood to the syncytiotrophoblasts. Isolation of trophoblast subtypes is technically...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (13): dev199561.
Published: 1 July 2021
...Hao Chen; Katherine E. Williams; Elaine Y. Kwan; Mirhan Kapidzic; Kenisha A. Puckett; Rayyan K. Aburajab; Joshua F. Robinson; Susan J. Fisher ABSTRACT During human pregnancy, cytotrophoblasts (CTBs) from the placenta differentiate into specialized subpopulations that play crucial roles in proper...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197673.
Published: 27 April 2021
... of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev187013.
Published: 8 September 2020
...Sara K. Taylor; Sahar Houshdaran; Joshua F. Robinson; Matthew J. Gormley; Elaine Y. Kwan; Mirhan Kapidzic; Birgit Schilling; Linda C. Giudice; Susan J. Fisher ABSTRACT The placenta releases large quantities of extracellular vesicles (EVs) that likely facilitate communication between the embryo...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev190371.
Published: 3 July 2020
... of the recombined mT/mG allele in the early post-implantation trophoblast and placenta. (A) Schematic representation of the inheritance of the recombined mT/mG allele in the trophoblast lineage. (B) Uterus with implantation sites dissected after embryo transfer of Tat-Cre-treated mT/mG blastocysts. (C) E6.5 embryo...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (22): dev163428.
Published: 27 November 2019
...Margherita Y. Turco; Ashley Moffett ABSTRACT The placenta is essential for normal in utero development in mammals. In humans, defective placental formation underpins common pregnancy disorders such as pre-eclampsia and fetal growth restriction. The great variation in placental types across mammals...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (16): dev162305.
Published: 16 April 2018
...Cheryl Q. E. Lee; Margherita Y. Turco; Lucy Gardner; Benjamin D. Simons; Myriam Hemberger; Ashley Moffett ABSTRACT During pregnancy the trophoblast cells of the placenta are the only fetal cells in direct contact with maternal blood and decidua. Their functions include transport of nutrients...
Includes: Supplementary data
Journal Articles