...Vijay Pratap Singh; Huzaifa Hassan; Fengyan Deng; Dai Tsuchiya; Sean McKinney; Kevin Ferro; Jennifer L. Gerton ABSTRACT The placenta is essential for reproductive success. The murine placenta includes polyploid giant cells that are crucial for its function. Polyploidy occurs broadly in nature...

... to exit the placenta and invade into the uterus where they restructure the vasculature. Invasive trophoblast cells arise from a well-defined compartment within the placenta, referred to as the junctional zone in rat and the extravillous trophoblast cell column in human. In this study, we investigated...

...Chang Cao; Mark D. Fleming ABSTRACT Fetal development relies on adequate iron supply by the placenta. The placental syncytiotrophoblasts (SCTB) express high levels of iron transporters, including ferroportin1 ( Fpn1 ). Whether they are essential in the placenta has not been tested directly, mainly...

...Laina Freyer; Yvan Lallemand; Pascal Dardenne; Alina Sommer; Anne Biton; Elisa Gomez Perdiguero ABSTRACT Hofbauer cells (HBCs) are tissue macrophages of the placenta thought to be important for fetoplacental vascular development and innate immune protection. The developmental origins of HBCs remain...

... promoted proliferation identical to Rocki, indicating an all-encompassing upstream regulation. Morphological differentiation included formation of binucleate cells and infrequent multinucleate syncytia, features we also localize in the in vivo bovine placenta. Collectively, we demonstrate a central role...

.... ( 2014 ). The placenta harbors a unique microbiome . Sci. Transl. Med. 6 , 237ra65 . 10.1126/scitranslmed.3008599 Aghaeepour , N. , Ganio , E. A. , Mcilwain , D. , Tsai , A. S. , Tingle , M. , Van Gassen , S. , Gaudilliere , D. K. , Baca , Q. , McNeil , L...

... is known about the processes controlling human CTB progenitor maintenance and differentiation. To address this, we established a single cell RNA sequencing (scRNA-seq) dataset from first trimester placentas to identify cell states important in trophoblast progenitor establishment, renewal...

... the importance of ICR1 in the placental production of hormones that promote maternal nutrient allocation to the fetus is unknown. To address this, we used a novel mouse model to selectively delete ICR1 in the endocrine junctional zone (Jz) of the mouse placenta (Jz-ΔICR1). The Jz-ΔICR1 mice exhibit increased...

... the uterine surface, these progenitors assume a different fate, becoming cancer-like cells that invade its lining and blood vessels. The latter process physically connects the placenta to the mother and shunts uterine blood to the syncytiotrophoblasts. Isolation of trophoblast subtypes is technically...

...Hao Chen; Katherine E. Williams; Elaine Y. Kwan; Mirhan Kapidzic; Kenisha A. Puckett; Rayyan K. Aburajab; Joshua F. Robinson; Susan J. Fisher ABSTRACT During human pregnancy, cytotrophoblasts (CTBs) from the placenta differentiate into specialized subpopulations that play crucial roles in proper...

... of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other...

...Sara K. Taylor; Sahar Houshdaran; Joshua F. Robinson; Matthew J. Gormley; Elaine Y. Kwan; Mirhan Kapidzic; Birgit Schilling; Linda C. Giudice; Susan J. Fisher ABSTRACT The placenta releases large quantities of extracellular vesicles (EVs) that likely facilitate communication between the embryo...

... of the recombined mT/mG allele in the early post-implantation trophoblast and placenta. (A) Schematic representation of the inheritance of the recombined mT/mG allele in the trophoblast lineage. (B) Uterus with implantation sites dissected after embryo transfer of Tat-Cre-treated mT/mG blastocysts. (C) E6.5 embryo...

... are at higher risk for abnormal placentation. Using a mouse model, we investigate how individual procedures contribute to placental defects across development. Assisted reproductive technologies Fetal growth Placenta Preeclampsia sFLT1 References Adamson , D. G. , Zegers-Hochschild...

...Margherita Y. Turco; Ashley Moffett ABSTRACT The placenta is essential for normal in utero development in mammals. In humans, defective placental formation underpins common pregnancy disorders such as pre-eclampsia and fetal growth restriction. The great variation in placental types across mammals...

... from poor functioning of the placenta. In vivo models of maternal stressors, such as nutrient deficiency, and placental insufficiency often focus on inadequate growth of the fetus and placenta in late gestation. These studies rarely investigate the origins of poor placental formation in early gestation...

.../bioinformatics/btu638 Anson-Cartwright , L. , Dawson , K. , Holmyard , D. , Fisher , S. J. , Lazzarini , R. A. and Cross , J. C. ( 2000 ). The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta . Nat. Genet.   25 , 311 - 314...

...Cheryl Q. E. Lee; Margherita Y. Turco; Lucy Gardner; Benjamin D. Simons; Myriam Hemberger; Ashley Moffett ABSTRACT During pregnancy the trophoblast cells of the placenta are the only fetal cells in direct contact with maternal blood and decidua. Their functions include transport of nutrients...

...Wen-Lin Chang; Ya-Wei Liu; Yan-Li Dang; Xiang-Xiang Jiang; Honglin Xu; Xing Huang; Yan-Ling Wang; Haibin Wang; Cheng Zhu; Li-Qun Xue; Hai-Yan Lin; Wenxiang Meng; Hongmei Wang ABSTRACT Proper differentiation of trophoblast cells in the human placenta is a prerequisite for a successful pregnancy...

... differences in early placental development between mouse and human, but a detailed comparison of placentae in these two species is missing. We set out to compare placentae from both species across gestation, with a focus on trophoblast progenitor markers. We found that CDX2 and ELF5, but not EOMES...