...Ning-Ning Song; Pengcheng Ma; Qiong Zhang; Lei Zhang; Huishan Wang; Longlong Zhang; Liang Zhu; Chun-Hui He; Bingyu Mao; Yu-Qiang Ding ABSTRACT Noradrenaline belongs to the monoamine system and is involved in cognition and emotional behaviors. Phox2a and Phox2b play essential but non-redundant roles...

... pancreas, we defined the chronology of migration and differentiation of neural crest cells in the pancreas, and tested their role in the development of the islets. The homeodomain transcription factor Phox2b marks the neural precursors from the neural crest that colonize the gut to form the enteric nervous...

...Marsha E. Lucas; Frank Müller; Roland Rüdiger; Paul D. Henion; Hermann Rohrer The basic helix-loop-helix transcription factor Hand2 , together with Ascl1, Phox2a, Phox2b and Gata2/Gata3 , is induced by bone morphogenetic proteins in neural crest-derived precursor cells during sympathetic neuron...

.... Pattyn, A., Morin, X., Cremer, H., Goridis, C. and Brunet, J. F. ( 1997 ). Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development 124 , 4065 -4075. Pattyn, A., Morin, X., Cremer, H., Goridis, C. and Brunet, J. F. ( 1999...

..., which includes Mash1, Phox2b, Hand2 and Phox2a. Here, we have studied the function of Gata2 and Gata3 zinc-finger transcription factors in autonomic neuron development. In the chick, Gata2 but not Gata3 is expressed in developing sympathetic precursor cells. Gata2 expression starts after Mash1, Phox2b...

... of a program that controls pan-neuronal differentiation and of a program that specifies neuronal subtype identity, but how these programs are coordinated in time and space is not well understood. Our previous loss- and gain-of-function studies have defined Phox2b as a homeodomain transcription factor...

... for neuronal but not for neuroendocrine differentiation. We show now that MASH1 function is necessary for the development of the vast majority of chromaffin cells. Most adrenal medullary cells in Mash1 –/– mice identified by Phox2b immunoreactivity, lack the catecholaminergic marker tyrosine hydroxylase. Mash1...

..., but how the regulation of cell cycle withdrawal intersects with that of cell fate determination is poorly understood. Here we show by both loss- and gain-of-function experiments that the neuronal-subtype-specific homeodomain transcription factor Phox2b drives progenitor cells to become post-mitotic...

... implicated the homeobox genes Pax6 and Nkx2 . 2 in the early divergence of the transcriptional programme of hindbrain somatic and visceral motor neuronal differentiation. We provide genetic evidence that the paired-like homeodomain protein Phox2b is required for the formation of all branchial and visceral...

... and parasympathetic ganglia and, as we show here, the nuclei of the IIIrd and IVth cranial nerves. We now report on the characterization of Phox2b, a close relative of Phox2a, with an identical homeo-domain. Phox2a and Phox2b are co-expressed at most sites, therefore suggesting a broader role for Phox2 genes...