...Ning-Ning Song; Pengcheng Ma; Qiong Zhang; Lei Zhang; Huishan Wang; Longlong Zhang; Liang Zhu; Chun-Hui He; Bingyu Mao; Yu-Qiang Ding ABSTRACT Noradrenaline belongs to the monoamine system and is involved in cognition and emotional behaviors. Phox2a and Phox2b play essential but non-redundant roles...

... that involves the establishment of Notch signaling in ventral midline cells. On the other hand, lateral DN progenitors that do not appear to originate from the floor plate are selectively ablated in Lmx1b mutants. In addition, we also reveal an unanticipated role for Lmx1b in regulating Phox2a expression...

... in early differentiation and survival of the placodally derived cranial sensory neurons. We thank J.-F. Brunet for kindly providing the Phox2a and Phox2b , D. Anderson for the SCG10 , M. Wegner for the Sox10 in situ probes and J. Davenport for technical assistance. Photomicroscopy and image...

..., progenitor cells fail to express the basic helix-loop-helix gene neurogenin that is essential for the formation of neuronal precursors, and the paired homeodomain containing gene phox2a that is essential for neuronal differentiation and maintenance. Consequently, increased cell death is detected indicating...

... as in the opV placode. In contrast, Pax3-negative cells in the grafted ectoderm are induced to express the epibranchial placode marker Pax2 and form neurons in the nodose ganglion that express the epibranchial neuron marker Phox2a on the same schedule as host nodose neurons. They also project neurites along...

.... , Kapur , R. P. , Goridis , C. and Brunet , J.-F. ( 1997 ). Defects in sensory and autonomic ganglia and absence of Locus Coeruleus in mice deficient for the homeobox gene Phox2a . Neuron 18 , 411 – 423 . Nieto , M. A. , Sargent , M. G. , Wilkinson , D. G...

... Phox2a, a positive regulator of the dopamine β-hydroxylase gene and that a subset of them depend on it for their survival. We now report that expression of Phox2a is abolished or massively altered in the Mash1 −/− mutants, both in the noradrenergic centres of the brain and in peripheral autonomic ganglia...

...) with bone morphogenetic protein-2 (BMP-2) leads to an induction of MASH1 expression and consequent autonomic neuronal differentiation. We now show that BMP2 also induces expression of the paired homeodomain transcription factor Phox2a, and the GDNF/NTN signalling receptor tyrosine kinase c-RET. Constitutive...

... Phox2a , which is expressed in differentiating neurons of the central and peripheral autonomic nervous system as well as in motor nuclei of the hindbrain. Targeted deletion of the Phox2a gene affects part of the structures in which it is expressed: the locus coeruleus, visceral sensory...