...Ning-Ning Song; Pengcheng Ma; Qiong Zhang; Lei Zhang; Huishan Wang; Longlong Zhang; Liang Zhu; Chun-Hui He; Bingyu Mao; Yu-Qiang Ding ABSTRACT Noradrenaline belongs to the monoamine system and is involved in cognition and emotional behaviors. Phox2a and Phox2b play essential but non-redundant roles...

... that involves the establishment of Notch signaling in ventral midline cells. On the other hand, lateral DN progenitors that do not appear to originate from the floor plate are selectively ablated in Lmx1b mutants. In addition, we also reveal an unanticipated role for Lmx1b in regulating Phox2a expression...

... at E9.5( Fig. 7I ), suggesting that the Eya1-Six1 regulatory pathway also operates in the epibranchial placodal development. Bmp7 in the pharyngeal endoderm has been shown to act as a signaling molecule for epibranchial placode induction and it can induce Phox2a -positive neurons directly from...

..., progenitor cells fail to express the basic helix-loop-helix gene neurogenin that is essential for the formation of neuronal precursors, and the paired homeodomain containing gene phox2a that is essential for neuronal differentiation and maintenance. Consequently, increased cell death is detected indicating...