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Keywords: Phosphorylation
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (12): dev201572.
Published: 13 June 2023
.... We further confirmed that PATL2 phosphorylation occurs in the oocyte maturation process and identified the S279 phosphorylation site using phosphoproteomics. We found that the S279D mutation decreased the protein level of PATL2 and led to subfertility in Palt2 S279D knock-in mice. Our work reveals...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2023) 150 (2): dev201119.
Published: 18 January 2023
... is required for tyrosine phosphorylation at bicellular (bAJ) and tricellular (tAJ) junctions in germband cells, and localizes to hotspots of mechanical tension. The role of Src42A was investigated using maternal RNAi and CRISPR-Cas9-induced germline mosaics. We find that, during cell intercalations, Src42A...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Plant development
Journal: Development
Development (2021) 148 (6): dev196378.
Published: 21 March 2021
... receptor-like kinase (L-LecRLK). AP1 is localized to the plasma membrane and its transcript is highly accumulated in pollen during the starch synthesis phase. RNA-seq and phosphoproteomic analysis revealed that the expression/phosphorylation levels of numerous genes/proteins involved in starch and sucrose...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (15): 3050–3061.
Published: 1 August 2014
... in craniofacial development and embryonic survival, altering Hand1 phosphoregulation, and consequently Hand1 dimerization affinities, in NCCs results in severe mid-facial clefting and neonatal death. Hand1 phosphorylation mutants exhibit a non-cell-autonomous increase in pharyngeal arch cell death accompanied...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2216–2224.
Published: 1 June 2014
... in regeneration and repair. However, generation of physiologically mature neurons in vitro remains problematic. Here we demonstrate the cell-cycle-dependent phosphorylation of a key reprogramming transcription factor, Ascl1, on multiple serine-proline sites. This multisite phosphorylation is a crucial regulator...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (24): 4505–4513.
Published: 15 December 2012
... differentiation activities. In Drosophila , the conserved serine 138 residue in Maelstrom is required for its phosphorylation, an event that promotes oocyte determination. Phosphorylation of Maelstrom is required for the repression of the pachytene checkpoint protein Sir2, but not for transposon silencing...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (2): 325–334.
Published: 15 January 2012
... factor required for ac-sc expression, the expression of which coincides temporally with that of ac-sc in the notum, is Wingless (Wg; also known as Wnt). Wingless downregulates the activity of the serine/threonine kinase Shaggy (Sgg; also known as GSK-3). We demonstrate that Scute is phosphorylated by Sgg...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (18): 3109–3119.
Published: 15 September 2009
... that phosphorylation of two evolutionary conserved MLC-4 serine and threonine residues is important for myosin II activity and organization. Finally, in an RNAi screen for potential myosin regulatory light chain kinases, we found that the ROCK, PAK and MRCK homologs act redundantly. The combined loss of ROCK and PAK...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (5): 829–837.
Published: 1 March 2008
... understood. We have previously shown that the EGFR RTK pathway causes phosphorylation and downregulation of Groucho, a global co-repressor that is widely used by many developmentally important repressors for silencing their various targets. Here, we use specific antibodies that reveal the dynamics of Groucho...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (22): 4485–4493.
Published: 15 November 2006
... Recycling Receptor dynamics Half-life Phosphorylation Synaptic activity At central synapses, recycling of postsynaptic receptors plays a crucial role in synaptic plasticity. For example, during long-term potentiation,synaptic strength is enhanced by an increased recruitment of recycledα-amino-5...
Journal Articles
Journal: Development
Development (2005) 132 (15): 3505–3513.
Published: 1 August 2005
... like wild type, suggesting that the SMA-4 C terminus is dispensable. Using a combination of different C-terminal mutations in SMA-2 and SMA-3, we found a complex set of requirements for Smad-phosphorylation state that are specific to each outcome. Finally, we detected a physical interaction of SMA-3...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3545–3553.
Published: 1 August 2002
... but lacks a signal sequence for secretion and is internalised by a non-endocytic process. We show that phosphorylation of a serine-rich domain within Engrailed 2 by the protein kinase CK2 specifically inhibits Engrailed 2 secretion. The availability of the serine-rich domain to CK2 is highly increased when...
Journal Articles
Journal: Development
Development (2002) 129 (8): 1925–1933.
Published: 15 April 2002
... autophosphorylation in the signaling process. We first show that Pelle phosphorylation can be detected transiently in early embryos, concomitant with activation of signaling. Importantly, Pelle phosphorylation is enhanced in a gain-of-function Toll mutant (Toll 10b ), but decreased by loss-of-function Toll alleles...