... that electrostatically binds the PM phosphoinositides PI4P and PI(4,5)P 2 . Electrostatic targeting by the polybasic domain contributes significantly to the PM localization of Dlg in follicular and early embryonic epithelial cells, and is crucial for Dlg to regulate both polarity and tumorigenesis. The electrostatic PM...

... structures and regulates asymmetric division by controlling actin organization as well as cell polarity in the one-cell C. elegans embryo. C. elegans embryo Phosphoinositides PIP 2 Asymmetric cell division Actin PAR polarity Asymmetric division generates cellular diversity...

...Ingo Heilmann The membranes of eukaryotic cells create hydrophobic barriers that control substance and information exchange between the inside and outside of cells and between cellular compartments. Besides their roles as membrane building blocks, some membrane lipids, such as phosphoinositides...

... ( ops ), meristematic activity and consequently overall root growth are strongly reduced. Second site mutation in the protophloem-specific presumed phosphoinositide 5-phosphatase COTYLEDON VASCULAR PATTERN 2 ( CVP2 ), but not in its homolog CVP2-LIKE 1 ( CVL1 ), partially rescues brx defects. Consistent...

...Andrea Becchetti; Michael Whitaker ABSTRACT Lithium is a classical inhibitor of the phosphoinositide pathway and is teratogenic. We report the effects of lithium on the first cell cycles of sea urchin ( Lytechinus pictus ) embryos. Embryos cultured in 400 mM lithium chloride sea water showed marked...