...-computed tomography (micro-CT), have been incorporated into the high-throughput embryo pipeline of the International Mouse Phenotyping Consortium (IMPC). This project generates large volumes of raw data that cannot be immediately exploited without significant resources of personnel and expertise. Thus...

...Nicolas Toussaint; Yushi Redhead; Marta Vidal-García; Lucas Lo Vercio; Wei Liu; Elizabeth M. C. Fisher; Benedikt Hallgrímsson; Victor L. J. Tybulewicz; Julia A. Schnabel; Jeremy B. A. Green ABSTRACT Characterising phenotypes often requires quantification of anatomical shape. Quantitative shape...

... and developmental biology techniques. The ability to use μ-CT as a whole-animal phenotyping tool in this context could significantly enhance our mechanistic understanding of development, anatomy and disease. Here, we establish μ-CT as a versatile and effective tool to complement traditional imaging platforms...

...Michael D. Wong; Yoshiro Maezawa; Jason P. Lerch; R. Mark Henkelman The International Mouse Phenotyping Consortium (IMPC) plans to phenotype 20,000 single-gene knockout mice to gain an insight into gene function. Approximately 30% of these knockout mouse lines will be embryonic or perinatal lethal...