...Pengfei Xu; Bartosz Balczerski; Amanda Ciozda; Kristin Louie; Veronika Oralova; Ann Huysseune; J. Gage Crump ABSTRACT Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the embryonic pharyngeal arches. How complex signaling information is integrated to specify...

... Fgf8 Cardiovascular Outflow tract Congenital heart disease Truncus Arteriosus Transposition 22q11 deletion syndrome Pharyngeal arches Neural crest DiGeorge syndrome Cardiogenesis requires specification, differentiation, proliferation and migration of cell populations...

... late embryogenesis, and exhibit defects in neural tube closure and in the development of the tail bud and pharyngeal arches. However, the mutant receptor is able to drive Fgfr1 functions during gastrulation and somitogenesis, and drives normal MAPK responses to Fgf. These findings indicate that Fgfr1...

... Neural crest Endoderm Pharyngeal arches Pharyngeal pouches BMP Segmentation Development of the peripheral nervous system involves the coordinated development of two uniquely vertebrate cell types, placodes and neural crest. During head development, focal thickenings of ectoderm called...

... construction are incompletely understood. Zebrafish embryos homozygous for jellyfish ( jef )mutations show craniofacial defects and lack cartilage elements of the neurocranium, pharyngeal arches, and pectoral girdle similar to humans with campomelic dysplasia. We show that two alleles of jef contain mutations...

... nervous system abnormalities. Because ablation of neural crest in chicks produces many features of the deletion 22q11 syndrome, it has been proposed that haploinsufficiency in this region impacts neural crest function during cardiac and pharyngeal arch development. Few factors required for migration...

.... Using molecular and lineage analysis in this double mutant background we demonstrate that presumptive rhombomere 4, the major site of origin of the second pharyngeal arch neural crest, is reduced in size and has lost the ability to generate neural crest cells. Grafting experiments using wild-type cells...