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Keywords: Pharyngeal arch
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Journal Articles
Journal: Development
Development (2020) 147 (24): dev194738.
Published: 23 December 2020
...Kazunori Okada; Shinji Takada ABSTRACT Pharyngeal arches (PAs) are segmented by endodermal outpocketings called pharyngeal pouches (PPs). Anterior and posterior PAs appear to be generated by different mechanisms, but it is unclear how the anterior and posterior PAs combine. Here, we addressed...
Journal Articles
Journal: Development
Development (2020) 147 (3): dev185256.
Published: 03 February 2020
... Neural crest cells Pharyngeal arch Pharynx Tbx1 22q11.2 deletion syndrome Mouse The pharynx is essential for feeding, breathing and speech, and the pharyngeal arches (PAs), segmental structures in the vertebrate embryo, play a crucial role in pharyngeal development. Two types of mesenchymal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev157438.
Published: 25 January 2018
.... TFAP2 AP-2 Neural crest Mandible Maxilla Homeobox Pharyngeal arch Branchial arch DLX Funding This work was funded by the National Institutes of Health (F32DE023709, 1K99DE026823, 2R01 DE12728 and 1U01DE024429). Deposited in PMC for release after 12 months. Data...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1800–1810.
Published: 15 May 2016
...Kazunori Okada; Keiji Inohaya; Takeshi Mise; Akira Kudo; Shinji Takada; Hiroshi Wada ABSTRACT A striking characteristic of vertebrate development is the pharyngeal arches, which are a series of bulges on the lateral surface of the head of vertebrate embryos. Although each pharyngeal arch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (21): 4386–4397.
Published: 01 November 2013
..., whereas its late inactivation results in a hypomorphic auricle, mimicking the human HOXA2 mutant condition. By genetic fate mapping we found that the mouse auricle (or pinna) derives from the Hoxa2 -expressing neural crest-derived mesenchyme of the second pharyngeal arch, and not from a composite of first...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (23): 5135–5146.
Published: 01 December 2011
... signals, such as Endothelin 1 (Edn1) and Jagged/Notch, which pattern the dorsal-ventral (DV) axis of the pharyngeal arches. Here, we use transgenic zebrafish to monitor and perturb BMP signaling during arch formation. With a BMP-responsive transgene, Tg(Bre:GFP), we show active BMP signaling in neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 339–348.
Published: 15 January 2011
... . Zhang Z. , Huynh T. , Baldini A. ( 2006 ). Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development . Development 133 , 3587 - 3595 . Zweier C. , Sticht H. , Aydin-Yaylagul I. , Campbell C. E...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (24): 4307–4316.
Published: 15 December 2010
... tract septation and thymic and dorsal root ganglia development. Dicer mutant embryos had reduced expression of Dlx2 , a transcriptional regulator of pharyngeal arch development, in the first pharyngeal arch (PA1). miR-452 was enriched in NCCs, was sufficient to rescue Dlx2 expression in Dicer mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1137–1147.
Published: 01 April 2010
...-like phenotypes. Additionally, reducing the gene dosage of Fgf8 rescued pharyngeal arch artery defects caused by loss of Ctnnb1 . These findings identify Wnt—β-catenin signaling as a crucial upstream regulator of a Tbx1—Fgf8 signaling pathway and suggest that factors that affect Wnt—β-catenin signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (11): 1935–1946.
Published: 01 June 2008
... mutants display anterior transformations of pharyngeal arches due to progressive loss of anterior Hox gene expression. Brpf1 functions in association with the histone acetyltransferase Moz (Myst3), an interaction mediated by the N-terminal domain of Brpf1, and promotes histone acetylation in vivo. Brpf1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (4): 755–765.
Published: 15 February 2008
...) receptors. During embryogenesis, the Edn1/Ednra signaling is thought to regulate the dorsoventral axis patterning of pharyngeal arches via Dlx5/Dlx6 upregulation. To further clarify the underlying mechanism, we have established mice in which gene cassettes can be efficiently knocked-in into the Ednra locus...
Journal Articles
Journal: Development
Development (2007) 134 (2): 335–345.
Published: 15 January 2007
.... Knockdown of Ednra1 leads to fusions between upper- and lower-jaw cartilages, whereas the combined loss of Ednra1 and Ednra2 eliminates the lower jaw, similar to edn1 -/- mutants. edn1 is expressed in pharyngeal arch ectoderm, mesoderm and endoderm. Tissue-mosaic studies indicate that, among these tissues...
Journal Articles
Journal: Development
Development (2006) 133 (6): 1069–1077.
Published: 15 March 2006
... of post-migratory neural crest cells, that gives rise to the cartilages of the anterior neurocranium and the pterygoid process of the palatoquadrate in the upper jaw, condenses upon the upper or roof layer of the stomodeal ectoderm in the first pharyngeal arch. We observe that in mutants for the Hh co...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (25): 6361–6374.
Published: 22 December 2003
... with a constellation of heart, outflow tract, great vessel and pharyngeal gland defects that phenocopies human deletion 22q11 syndromes, such as DiGeorge. We postulate that these Fgf8 hypomorphic phenotypes result from disruption of local FGF8 signaling from pharyngeal arch epithelia to mesenchymal cells populating...
Journal Articles
Journal: Development
Development (2003) 130 (9): 1749–1758.
Published: 01 May 2003
..., Fig. 2F ). † Author for correspondence (e-mail: helms@itsa.ucsf.edu ) 14 1 2002 © 2003. 2003 Craniofacial development Patterning Fgf Shh Neuroectoderm Facial ectoderm Neural crest Frontonasal process FNP Branchial arch Pharyngeal arch Quail Chick...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1353–1365.
Published: 01 April 2003
... and joints in the anterior pharyngeal arches of young larvae. Here we present genetic analyses in the zebrafish of two edn1 downstream targets, the bHLH transcription factor Hand2 and the homeobox transcription factor Bapx1, that mediate dorsoventral (DV) patterning in the anterior pharyngeal arches. First...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1339–1351.
Published: 01 April 2003
...Charles B. Kimmel; Bonnie Ullmann; Macie Walker; Craig T. Miller; Justin G. Crump Endothelin 1 (Edn1), a secreted peptide expressed ventrally in the primordia of the zebrafish pharyngeal arches, is required for correct patterning of pharyngeal cartilage development. We have studied mutants...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4613–4625.
Published: 01 October 2002
...Radwan Abu-Issa; Graham Smyth; Ida Smoak; Ken-ichi Yamamura; Erik N. Meyers We present here an analysis of cardiovascular and pharyngeal arch development in mouse embryos hypomorphic for Fgf8 . Previously, we have described the generation of Fgf8 compound heterozygous ( Fgf8 neo/– ) embryos...