...Michael Morales; Anna P. Findley; Diana M. Mitchell ABSTRACT To clarify our understanding of glial phagocytosis in retinal development, we used real-time imaging of larval zebrafish to provide cell-type specific resolution of this process. We show that radial Müller glia frequently participate...

... and degeneration, and crucial signaling pathways between neurons and glia are necessary for the execution of phagocytosis. Chemokine-like mushroom body neuron-secreted Orion is essential for astrocyte infiltration into the γ axon bundle leading to γ axon pruning. Here, we show a role of Orion in debris engulfment...

... epithelial cell phagocytosis and cytokine production . J. Innate Immun. 9 , 529 - 545 . 10.1159/000478042 Dorrell , M. I. , Aguilar , E. and Friedlander , M. ( 2002 ). Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template...

... to the lesion site, where they phagocytose cellular debris. Microglial phagocytosis can have both beneficial (e.g. debris clearance) and detrimental (e.g. respiratory burst, phagoptosis) consequences. Hence, whether the overall effect of microglial phagocytosis after brain injury in vivo is neuroprotective...

... the lung in three waves, each giving rise to a distinct lineage that expresses different markers, resides in a different location and renews in a different way. Lineage tracing Lung development Lung macrophage Parabiosis Phagocytosis Macrophages are professional phagocytes found in all...

... cells. We further establish that Mex3b acts to regulate the cortical level of activated Rap1, a small G protein controlling phagocytosis and cell-cell interaction, through the activation and transport of Rap1GAP. The active form of Rap1 (Rap1-GTP) is abnormally increased at the membrane cortex...

... ) Competing interests statement The authors declare no competing financial interests. 8 2 2011 © 2011. 2011 Apoptosis Cell death Phagocytosis Caenorhabditis elegans Tissue homeostasis and organ formation requires a physiological balance that regulates proliferation...

.... Foley, K. and Cooley, L. ( 1998 ). Apoptosis in late stage Drosophila nurse cells does not require genes within the H99 deficiency. Development 125 , 1075 -1082. Franc, N. C. ( 2002 ). Phagocytosis of apoptotic cells in mammals, Caenorhabditits elegans and Drosophila melanogaster...

... and prospero expression. We suggest that apoptosis is triggered by a cell autonomous mechanism. * Author for correspondence (e-mail: [email protected] ) 4 10 2002 © 2003. 2003 Apoptosis Axogenesis gcm Microchaete Phagocytosis p35 reaper hid grim Asymmetric...

... effect, but inactivating two or more genes perturbed both axon outgrowth and guidance. mig-2 and ced-10 also have redundant functions in some cell migrations. By contrast, ced-10 is uniquely required for cell-corpse phagocytosis, and mig-2 and rac-2 have only subtle roles in this process. Rac activators...

... and cleared by macrophages. We show that in a macrophageless mouse embryo, null for the haemopoetic-lineage-specific transcription factor, PU.1, the task of phagocytosis is taken over by ‘stand-in’ mesenchymal neighbours in a clear example of cell redundancy. However, it takes three times as many...

.... and Ross , J. A. ( 1992 ). The biology of the macrophage . In The Macrophage . (ed. C. E. Lewis and J. D. McGee ), pp. 1 – 74 . Oxford University Press , Oxford . Cannon , G. J. and Swanson , J. A. ( 1992 ). The macrophage capacity for phagocytosis . J. Cell Sci...