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Keywords: Perlecan
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200456.
Published: 16 May 2022
... composition and mechanical properties of the basement membrane underlying the follicle epithelium of Drosophila egg chambers. We find that the Laminin and Collagen IV networks largely persist in the absence of the other components. Moreover, we show that Perlecan and Collagen IV, but not Laminin or Nidogen...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev168948.
Published: 16 January 2019
... Collagen, Perlecan and Nidogen/entactin (NDG). Recent in vivo studies challenged the initially proposed role of NDG as a major ECM linker molecule by revealing dispensability for viability and BM formation. Here, we report the characterization of the single Ndg gene in Drosophila. Embryonic Ndg expression...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (10): dev158881.
Published: 14 May 2018
... of tissues with extracellular matrix proteins. Here we show that the conserved basement membrane protein UNC-52/Perlecan is required for establishing the correct number of the highly ordered dendritic trees in the somatosensory neuron PVD in Caenorhabditis elegans . This function is dependent on four...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4177–4186.
Published: 1 December 2007
... morphogenesis. Heparanase, an endoglycosidase, colocalized with perlecan in the basement membrane and in epithelial clefts of SMGs. Inhibition of heparanase activity in organ culture decreased branching morphogenesis, and this inhibition was rescued specifically by FGF10 and not by other FGFs. By contrast...
Journal Articles
Journal: Development
Development (2006) 133 (19): 3805–3815.
Published: 1 October 2006
...) as a model system, we show that the ECM molecule Perlecan(Pcan) is required for maintenance of epithelial-cell polarity. Follicle cells that lack Pcan develop polarity defects similar to those of Dg mutant cells. Furthermore, Dg depends on Pcan but not on Laminin A for its localization in the basal-cell...
Journal Articles
Journal: Development
Development (2002) 129 (21): 4999–5008.
Published: 1 November 2002
...Caroline A. Spike; Andrew G. Davies; Jocelyn E. Shaw; Robert K. Herman Previous work has shown that C. elegans MEC-8 is a putative RNA-binding protein that promotes specific alternative splices of unc-52 transcripts. unc-52 encodes homologs of mammalian perlecan that are located extracellularly...