... population. We also describe novel relationships between different populations of mural cells surrounding blood vessels. The periarterial niche of mature vessels has been described as a heterogeneous mix of vSMCs, fibroblasts and other cell populations. Intriguingly, we find NG2, a marker of pericytes...

... basement membranes, resulting in pathological blood–brain barrier integrity. Angiogenesis Extracellular matrix Brain microenvironment Blood vessel Vascular smooth muscle cell Astrocyte Pericyte Megalencephalic leukoencephalopathy with subcortical cysts 1 National Institute...

...Yu-Huan Shih; Daneal Portman; Feston Idrizi; Ann Grosse; Nathan D. Lawson ABSTRACT Pericytes reside in capillary beds where they share a basement membrane with endothelial cells and regulate their function. However, little is known about embryonic pericyte development, in part, due to lack...

...Nabila Bahrami; Sarah J. Childs ABSTRACT The thin endothelial wall of a newly formed vessel is under enormous stress at the onset of blood flow, rapidly acquiring support from mural cells (pericytes and vascular smooth muscle cells; vSMCs) during development. Mural cells then develop vasoactivity...

...Amber N. Stratman; Sofia A. Pezoa; Olivia M. Farrelly; Daniel Castranova; Louis E. Dye, III; Matthew G. Butler; Harwin Sidik; William S. Talbot; Brant M. Weinstein Mural cells (vascular smooth muscle cells and pericytes) play an essential role in the development of the vasculature, promoting...

... and the activation of the motile gene expression program. Conditional ablation of Mrtfa and Mrtfb specifically in the epicardium disrupts cell migration and leads to sub-epicardial hemorrhage, partially stemming from the depletion of coronary pericytes. Using lineage-tracing analyses, we demonstrate that sub...

... (M,green) and smooth muscle actin (N, red), revealing that smooth muscle cells located within the myocardial wall (arrows) express VEGFA. Asterisk denotes VEGFA-expressing myocardial cells. O, merged image of M,N. Fig. 3. HH signaling to the cardiomyoblast and pericyte is essential...

...Ulrich Tigges; Elizabeth Gore Hyer; Jeffrey Scharf; William B. Stallcup Vessel-like networks are quickly formed in subcutaneous FGF2-supplemented Matrigel plugs by two cell types: NG2 + pericytes and F4/80 + macrophages. Although not detected in these networks until 7 days after plug implantation...

... mutant mouse Pericyte Vasculature Bone The ontogeny of the skeleton, like that of so many embryonic tissues,begins when loose mesenchymal cells aggregate to form a condensation, and continues as a reiterative series of interactions between the condensed cells and their surrounding environment...

... (e-mail: [email protected] and [email protected] ) 8 3 2002 © 2002. 2002 Stem cells Endothelium Pericyte Angiogenesis Chimera Mesoderm Histogenesis Mouse Quail Our current appreciation of stem cells plasticity has changed dramatically in the last years...

...Heather C. Etchevers; Christine Vincent; Nicole M. Le Douarin; Gérard F. Couly ABSTRACT Most connective tissues in the head develop from neural crest cells (NCCs), an embryonic cell population present only in vertebrates. We show that NCC-derived pericytes and smooth muscle cells are distributed...

... function: in their early trophic effect and in providing pericytes to the forebrain meningeal blood vessels. The assumption of these roles by the cephalic neural crest may have been instrumental in the rostral expansion of the vertebrate forebrain over the course of evolution. * Author...

...Mats Hellström; Mattias Kalén; Per Lindahl; Alexandra Abramsson; Christer Betsholtz ABSTRACT Development of a vascular system involves the assembly of two principal cell types – endothelial cells and vascular smooth muscle cells/pericytes (vSMC/PC) – into many different types of blood vessels. Most...

...Laura E. Benjamin; Itzhak Hemo; Eli Keshet ABSTRACT Little is known about how the initial endothelial plexus is remodelled into a mature and functioning vascular network. Studying postnatal remodelling of the retina vasculature, we show that a critical step in vascular maturation, namely pericyte...

... fibres. * Present address: Laboratory of Developmental Biochemistry, National Institute for Medical Research, The Ridgeway, Mill Hill. London NW7 1AA, UK 11 06 1987 © 1987 by Company of Biologists 1987 minced muscle regeneration pericyte myogenesis 22/18...