.... FGF Notch Craniofacial development Enthesis Perichondrium Tendon Mouse National Institutes of Health 10.13039/100000002 1R01DE025222 R01 DE025222-01S1 T90DE021982 T90DE021982 March of Dimes Foundation 10.13039/100000912 36-FY15-233 Shriners Hospitals...

..., but likely also requires active Notch signals in the developing perichondrium. Interestingly, we observed an increase in Mmp13 expression by in situ hybridization within the osteogenic lineage of cartilage-specific RBPjκ-deficient ( Fig. 3Co ) and RBPjκ-deficient Notch GOF mutants ( Fig. 3Cp ) compared...

... for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 6 1 2011 © 2011. 2011 Endochondral ossification Pten Perichondrium FGF18 Dermo1 cre Osteoprogenitors Mouse Endochondral ossification...

... signaling is required for the effects of Hedgehog on hypertrophic differentiation and expression of Pthrp . We show that Sonic hedgehog (Shh), a functional substitute for Ihh, stimulates expression of Tgfb2 and Tgfb3 mRNA in the perichondrium of embryonic mouse metatarsal bones grown in organ cultures...

...Fanxin Long; Thomas F. Linsenmayer ABSTRACT Endochondral bone formation in vertebrates requires precise coordination between proliferation and differentiation of the participating chondrocytes. We examined the role of perichondrium in this process using an organ culture system of chicken embryonic...