...Tetyana Shandala; Stephen L. Gregory; Hazel E. Dalton; Masha Smallhorn; Robert Saint Pebble (Pbl)-activated RhoA signalling is essential for cytokinesis in Drosophila melanogaster . Here we report that the Drosophila citron gene encodes an essential effector kinase of Pbl-RhoA signalling in vivo...

...Masha Smallhorn; Michael J. Murray; Robert Saint Drosophila pebble ( pbl ) encodes a Rho-family GTP exchange factor (GEF) required for cytokinesis. The accumulation of high levels of PBL protein during interphase and the developmentally regulated expression of pbl in mesodermal tissues suggested...

... neuroblast sublin- eages. We show that these neuroblasts can be identified in embryos lacking both neuroblast cytokinesis and cell cycle progression ( string mutants) and in embryos lacking only neuroblast cytokinesis ( pebble mutants). We find that the unplugged and achaete genes are expressed normally...

...Gary Hime; Robert Saint ABSTRACT Mutations at the pebble locus of Drosophila melanogaster result in embryonic lethality. Examination of homo-zygous mutant embryos at the end of embryogenesis revealed the presence of fewer and larger cells which contained enlarged nuclei. Characterization...