... factors are known to function in definitive hematopoiesis, the microenvironment contributing to primitive hematopoiesis remains largely elusive. Here, we report that platelet-derived growth factor (PDGF) signaling is required for erythroid progenitor differentiation in zebrafish. Ablating pdgfαa (also...

...-cadherins during epithelial-to-mesenchymal transition (EMT). However, the mechanism that controls the upregulation of N-cadherin remains unknown. Here, we show that platelet-derived growth factor receptor alpha (PDGFRα) and its ligand platelet-derived growth factor A (PDGF-A) are co-expressed in migrating...

... migration, and that platelet-derived growth factor (Pdgf)appears to act as a guidance cue in this process. However, the mechanisms underlying this process at the individual cell level remain poorly understood. We have identified miles apart ( mil ) as a suppressor of defective anterior migration...

... interactions between the neural tube and adjacent ectoderm. This induction triggers expression of Pax3, ingression of placode cells and their differentiation into neurons. However, the molecular nature of the underlying signals remains unknown. Here, we investigate the role of PDGF signaling in ophthalmic...

... characteristic oligodendroglial markers. Aberrant expression of astrocytic and neuronal markers was not observed. Strikingly, we failed to detect PDGF receptor α expression in the mutant oligodendrocyte precursors, arguing that PDGF receptor α is under transcriptional control of Sox9 and Sox10. Altered PDGF...

... to spina bifida. * Author for correspondence (e-mail: [email protected] ) 2 11 2007 © 2008. 2008 Spina bifida PDGF PI3 kinase Cell migration S6K1 PAK1 Mouse Chick Although Rac1 activation is an important component of cell motility...

... for mediating the vessel effect on muscle and connective tissue. Since the PDGF receptors, Pdgfr β and Pdgfr α, are both expressed at a suitable time in muscle masses and muscle connective tissue, respectively, the inhibitory effect of PDGFB on muscle formation could be a consequence of the combined responses...

... PDGF Gastrulation Cell migration The migration of mesodermal cells away from their site of internalization is a conserved feature of vertebrate gastrulation, although the importance of this process on the mechanics of gastrulation may differ between taxonomic groups ( Winklbauer, 1994...

...Dalia Rosin; Eyal Schejter; Talila Volk; Ben-Zion Shilo Epithelial tissue functions depend largely on a polarized organization of the individual cells. We examined the roles of the Drosophila PDGF/VEGF receptor (PVR) in polarized epithelial cells, with specific emphasis on the wing disc epithelium...

... © 2003. 2003 PDGF VEGF PVF Ecdysone Border cells Cell migration Drosophila The conversion of stationary, epithelial cells to migratory, invasive cells is an important feature of embryonic development and tumor metastasis. The border cells of the Drosophila ovary have emerged...

... of vascular defects around E11.5 due to haemorrhage and vascular integrity defects. Vascular supporting cells did not develop appropriately. C3G-deficient fibroblasts responded to PDGF-BB abnormally, exhibited cell adhesion defects and lacked paxillin and integrin-β1-positive cell adhesions. In contrast...

... the significance of these observations, we have examined the role of PDGF signaling in the developing somite. PDGFA ligand expression was not detected in the myotome of Myf5 null mutant embryos and PDGFA promoter activity was regulated by Myf5 in vitro. PDGFA stimulated chondrogenesis in somite micromass cultures...

..., if not all, vessels begin as endothelial tubes that subsequently acquire a vSMC/PC coating. We have previously shown that PDGF-B is critically involved in the recruitment of pericytes to brain capillaries and to the kidney glomerular capillary tuft. Here, we used desmin and α-smooth muscle actin (ASMA...

... between PDGF and oligodendrogenesis by examining mice that lack either PDGF-A or PDGF-B. PDGF-A null mice had many fewer PDGFR α-progenitors than either wild-type or PDGF-B null mice, demonstrating that proliferation of these cells relies heavily (though not exclusively) on PDGF-AA homodimers. PDGF...

...Per Lindahl; Mats Hellström; Mattias Kalén; Linda Karlsson; Milos Pekny; Marcela Pekna; Philippe Soriano; Christer Betsholtz ABSTRACT Kidney glomerulus mesangial cells fail to develop in mice carrying targeted null mutations in the platelet-derived growth factor (PDGF)-B or PDGF-Rβ genes. We have...

...Paris Ataliotis; Karen Symes; Margaret M. Chou; Lap Ho; Mark Mercola ABSTRACT During Xenopus gastrulation, platelet-derived growth factor (PDGF) receptor-α is expressed in involuting marginal zone cells which migrate over ectodermal cells expressing PDGF-A. To investigate the role of PDGF...

...Elizabeth Noll; Robert H. Miller ABSTRACT During development, oligodendrocyte precursors undergo sequential stages of differentiation characterized by expression of distinct cell surface properties and proliferative responses. Although both PDGF and bFGF are mitogenic for these cells, the factors...

...Hardeep S. Mudhar; Richard A. Pollock,; Chiayeng Wang; Charles D. Stiles; William D. Richardson ABSTRACT We have used in situ hybridization to visualize cells in the developing rat retina and optic nerve that express mRNAs encoding the A and B chains of platelet-derived growth factor (PDGF...

... in the crest cell neuronal derivatives. These results suggest that functional PDGF α is required for the normal development of many non-neuronal crest-derived structures but not for the development of crest-derived neuronal structures. Abnormal development of the non-neuronal crest cells in Ph/Ph embryos...

... mammalian development. 30 11 1987 © 1988 by Company of Biologists 1988 growth factor mammal epidermal growth factor EGF insulin-like growth factor IGF-I IGF-II transforming growth factor-beta TGF heparin-binding growth factor HBGF platelet-derived growth factor PDGF...