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Keywords: Pbx1/Pbx2
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Journal Articles

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression

Terence D. Capellini, Giuseppina Di Giacomo, Valentina Salsi, Andrea Brendolan, Elisabetta Ferretti, Deepak Srivastava, Vincenzo Zappavigna, Licia Selleri
Journal: Development
Development (2006) 133 (11): 2263–2273.
https://doi.org/10.1242/dev.02395
Published: 1 June 2006
... development. In this study, we first uncover that Pbx1 and Pbx2 are co-expressed in the lateral plate and early limb field mesoderm. Later, Pbx2 is expressed throughout the limb, unlike Pbx1 , which is expressed only in the proximal bud. By exploiting a Pbx1/Pbx2 loss-of-function mouse model,we demonstrate...
View articletitled, Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression
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Includes: Supplementary data