... demonstrate that these cellular behaviors are Pbx dependent, as is the transcriptional regulation of the EMT driver Snail1. Furthermore, in the embryo, the majority of epithelial cells expressing high levels of Snail1 do not undergo apoptosis. Pbx1 loss- and gain-of-function in a tractable epithelial culture...

... mice implicate various transcription factors in spleen development,but the hierarchical relationships between these factors have not been explored. In this report, we establish a genetic network that regulates spleen ontogeny, by analyzing asplenic mice mutant for the transcription factors Pbx1, Hox11...

...Licia Selleri; Michael J. Depew; Yakop Jacobs; Sumit K. Chanda; Kwok Y. Tsang; Kathryn S. E. Cheah; John L. R. Rubenstein; Stephen O’Gorman; Michael L. Cleary Pbx1 and a subset of homeodomain proteins collaboratively bind DNA as higher-order molecular complexes with unknown consequences...

...John R. McWhirter; Martyn Goulding; Joshua A. Weiner; Jerold Chun; Cornelis Murre ABSTRACT Pbx1 is a homeodomain transcription factor that has the ability to form heterodimers with homeodomain proteins encoded by the homeotic selector (Hox) gene complexes and increase their DNA-binding affinity...