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Keywords: Pax9
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Journal Articles
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Human development
Journal: Development
Development (2020) 147 (21): dev189175.
Published: 24 June 2020
... is transiently exposed to reduced oxygen levels or to phenytoin, a drug known to cause embryonic hypoxia. In the absence of interacting environmental factors, the Mnp growth defect caused by Msx1 deficiency is modified by a Pax9 -dependent ‘morphogenetic regulation’, which modulates Mnp shape, rescues lip...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (18): dev177618.
Published: 23 September 2019
... genes, is expressed throughout the pharyngeal arches and is considered a key gene, when mutated, for the arch artery defects. Pax9 is expressed in the pharyngeal endoderm and is downregulated in Tbx1 mutant mice. We show here that Pax9 -deficient mice are born with complex cardiovascular malformations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3819–3828.
Published: 15 October 2017
... surgically and require complex life-long treatments. Our studies utilized the well-characterized Pax9 −/− mouse model with a consistent cleft palate phenotype to test small-molecule Wnt agonist therapies. We show that the absence of Pax9 alters the expression of Wnt pathway genes including Dkk1 and Dkk2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4709–4718.
Published: 01 December 2013
...Jing Zhou; Yang Gao; Yu Lan; Shihai Jia; Rulang Jiang Cleft palate is one of the most common birth defects in humans. Whereas gene knockout studies in mice have shown that both the Osr2 and Pax9 transcription factors are essential regulators of palatogenesis, little is known about the molecular...
Journal Articles
Journal: Development
Development (2010) 137 (18): 3025–3035.
Published: 15 September 2010
... Notch signalling Tooth Embryonic development Ameloblast Enamel Cell fate Tissue interactions Tbx1 Bmp4 FGF Barx1 Pax9 Pitx2 Mouse The Notch signalling pathway is an evolutionarily conserved mechanism that enables adjacent cells to adopt different fates ( Artavanis-Tsakonas et al...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (3): 473–482.
Published: 01 February 2003
...Isabel Rodrigo; Robert E. Hill; Rudi Balling; Andrea Münsterberg; Kenji Imai We have previously shown that the paired-box transcription factors Pax1 and Pax9 synergistically act in the proper formation of the vertebral column. Nevertheless, downstream events of the Pax1/Pax9 action...