...Maud Wurmser; Nathalie Chaverot; Rouba Madani; Hiroshi Sakai; Elisa Negroni; Josiane Demignon; Benjamin Saint-Pierre; Vincent Mouly; Helge Amthor; Stephen Tapscott; Carmen Birchmeier; Shahragim Tajbakhsh; Fabien Le Grand; Athanassia Sotiropoulos; Pascal Maire ABSTRACT Pax7 expression marks stem...

...Ziad Al Tanoury; Jyoti Rao; Olivier Tassy; Bénédicte Gobert; Svetlana Gapon; Jean-Marie Garnier; Erica Wagner; Aurore Hick; Arielle Hall; Emanuela Gussoni; Olivier Pourquié ABSTRACT Satellite cells (SC) are muscle stem cells that can regenerate adult muscles upon injury. Most SC originate from PAX7...

... concomitant absence of Shh expression. Hhip:CD4 electroporation has no effect on ventral Hb9 + motoneurons or dorsal Pax7 expression (both in red). (F) In contrast, fewer motoneurons are apparent adjacent to the sclerotome transfected with Hhip:CD4 (arrow). (G-G″) Disintegration of the FP 10 h following...

... elevated as the neural folds (NFs) form and fuse in the dorsal region of the closed neural tube, from where NC cells emigrate. In chick embryos, Pax7 is an early marker, and necessary component of NC development. Unlike other early NPB markers, which are co-expressed in lateral ectoderm, medial neural...

... cells with high Pax7 expression. By genetically modulating Notch activity, we demonstrate that activated Notch (NICD) blocks terminal differentiation in an Rbpj-dependent manner that is sufficient to sustain stem/progenitor cells throughout embryogenesis, despite the absence of committed progeny...

... ( [email protected] ; [email protected] ) Competing interests statement The authors declare no competing financial interests. © 2012. Muscle regeneration Pax7 Satellite cells Skeletal muscle Stem cells Skeletal muscle has evolved to allow precise movement...

... The authors declare no competing financial interests. 27 10 2011 © 2012. 2012 Neural crest induction FGF MAPK Smad Neural plate border Gastrulation Pax7 Chick The neural crest (NC) is a population of multipotent embryonic cells that migrates from the dorsal neural tube...

... Tcf4, a newly identified fibroblast marker, and Pax7, a satellite cell marker, we found that after injury satellite cells and fibroblasts rapidly proliferate in close proximity to one another. To test the role of satellite cells and fibroblasts in muscle regeneration in vivo, we created Pax7 CreERT2...

... repair that is widely held to be accomplished by the satellite cells lying between the muscle fiber plasmalemma and the basement membrane. Cell transplantation and lineage-tracing studies have demonstrated that Pax7-expressing (Pax7 + ) satellite cells can repair damaged muscle tissue repeatedly after...

... express Pax7, but overexpression of Pax7 in blastomeres of whole embryos that populate the myogenic areas does not induce the formation of additional satellite cells. Moreover, a dominant-negative construct, Pax7EnR , does not reduce satellite cell formation. Neither Pax7 nor other myogenic transcription...

... pits are capable of inducing bone, cartilage and ectopic PAX7 expression, but these effects were only observed in the facial grafts. Facial mesenchyme also supported the initial projection of the olfactory nerve and differentiation of the olfactory epithelium. Thus, the nasal placode has two roles...

... for regeneration. We further tracked single nuclear-GFP-labeled cells as they proliferated during regeneration, observing their spatial distribution, and ultimately their expression of the progenitor markers PAX7 and PAX6. Most progenitors generate descendents that expand along the anterior/posterior (A/P) axis...

... the transcription factor Pax7. Some remain on the external surface and some incorporate into the fast myotome, apparently by moving between differentiated slow fibres. The posterior cells of the somite, by contrast, elongate into medial muscle fibres. The surprising movement of the anterior somite cells...

... contains many muscle satellite cells. They are active in DNA replication, whereas the myonuclei are not. As in mammals, the satellite cells express pax7 . We show that a domain-swapped construct, pax7EnR , can antagonize pax7 function. Transgenic tadpoles were prepared containing pax7EnR driven by a heat...

... Epithelial to mesenchymal transition Muscle Myod Myf5 Pax3 Pax7 Somite The embryonic myotome is the source of all epaxial and hypaxial skeletal muscles. The mechanisms underlying myotome development were recently reevaluated ( Brent and Tabin,2002 ; Buckingham,2001 ; Hollway...

... embryonic neural tube development, including Pax6 , Pax7 and Msx1 . Furthermore, the expression of Sonic hedgehog ( Shh ) is localized to the ventral floor plate domain in both mature and regenerating spinal cord. Patched1 receptor expression indicated that hedgehog signaling occurs not only within...

... that maintain expression of PAX7,PAX3 and FREK. Given this dual fate, we asked whether single dermomyotome precursors generate both dermal and mitotic myoblast precursors, or alternatively, whether these cell types derive from distinct epithelial founders. Inovo clonal analysis revealed that single dermomyotome...

... these two different muscle regions recruit their myogenic content. Migration of single muscle precursors from the somite would be characterised by Pax3 and Pax7 expression, without MyoD . However, myotomal extension presents as an elongation of a process continuous with the myotome. It expresses...

...Roy C. Mootoosamy; Susanne Dietrich Most head muscles arise from the pre-otic axial and paraxial head mesoderm. This tissue does not form somites, yet expresses the somitic markers Lbx1 , Pax7 and Paraxis in a regionalised fashion. The domain set aside by these markers provides the lateral rectus...

...Eiji Matsunaga; Isato Araki; Harukazu Nakamura Pax3/7 is expressed in the alar plate of the mesencephalon. The optic tectum differentiates from the alar plate of the mesencephalon, and expression of Pax3/7 is well correlated to the tectum development. To explore the function of Pax3 and Pax7...