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Keywords: Pax6
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev198796.
Published: 13 May 2021
... allows for a developmental or physiological role to be assigned to the wild-type gene. We previously observed that the concurrent loss of Pax6 and Polycomb epigenetic repressors in Drosophila leads the eye to transform into a wing. This fate change is not seen when either factor is disrupted separately...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev185827.
Published: 23 December 2020
...’ called Pax6 , which is both necessary and sufficient for eye development. Yet precisely how Pax6 achieves this deeply homologous function is poorly understood. Using the chick as a model organism, we show that vertebrate Pax6 interacts with a pair of morphogen-coding genes, Tgfb2 and Fst , to form a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev184523.
Published: 26 June 2020
... fashion. The ventral telencephalon acts as an instructive tissue, but the importance of the diencephalon in TCA mapping is unknown. We report that disruption of diencephalic development by Pax6 deletion results in a thalamocortical projection containing mapping errors. We used conditional mutagenesis to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163691.
Published: 09 August 2018
... pigmented epithelium (RPE). Here, we describe a novel regulatory relationship between the RPE transcription factors Pax6 and Sox9 that controls the timing of RPE differentiation and the adjacent choroid maturation. We used a novel machine learning algorithm tool to analyze high resolution imaging of the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163329.
Published: 02 August 2018
...Luke R. Baker; Bonnie M. Weasner; Athena Nagel; Sarah D. Neuman; Arash Bashirullah; Justin P. Kumar ABSTRACT The transcription factor Pax6 is considered the master control gene for eye formation because (1) it is present within the genomes and retina/lens of all animals with a visual system; (2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev159764.
Published: 16 April 2018
... homologous transcription factors (TFs) that dictate species-specific cellular dynamics has remained elusive. Here, we dissect shared and divergent functions of Pax6 during amniote brain development. Comparative functional analyses revealed that the neurogenic function of Pax6 is highly conserved in the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev160754.
Published: 04 April 2018
... fate transformation occurs with either the individual loss of Polycomb proteins or the simultaneous reduction of the Pleiohomeotic repressive complex and Pax6. Interestingly, the requirement for retinal selector genes is limited to Pax6, as the removal of more downstream members does not lead to the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4432–4447.
Published: 01 December 2014
... factor Pax6, that are required for lens formation in vertebrates. This Review summarizes recent progress in the field, emphasizing the interplay between the diverse regulatory mechanisms employed to form lens progenitor and precursor cells and highlighting novel opportunities to fill gaps in our...
Journal Articles
Journal: Development
Development (2014) 141 (14): 2875–2884.
Published: 15 July 2014
... and class II transcription factors play important roles in patterning neural progenitors into domains with clear boundaries. Here, we provide evidence that the zinc-finger protein Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary through mutually repressive interactions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1292–1302.
Published: 15 March 2014
..., retina and retinal pigmented epithelium. Although the role of Pax6 in early lens development has been well documented, its role in optic vesicle neuroepithelium and early retinal progenitors is poorly understood. Here we show that conditional inactivation of Pax6 at distinct time points of mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (1): 28–38.
Published: 01 January 2014
... doublecortin and tyrosine hydroxylase as direct Meis targets in newly generated neurons and the OB, respectively. Furthermore, biochemical analyses revealed a previously unrecognized complex of Meis2 with Pax6 and Dlx2, two transcription factors involved in OB neurogenesis. The full pro-neurogenic activity of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2611–2618.
Published: 15 June 2013
... epidermal (EPI) cells and found that two miRNA families, miR-200 and miR-96, were uniquely downregulated in the NEP cells. We confirmed zinc-finger E-box-binding homeobox (ZEB) transcription factors as a target of the miR-200 family members and identified paired box 6 (PAX6) transcription factor as the new...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (10): 2190–2202.
Published: 15 May 2013
... functions. Pax6 is a highly conserved transcription factor crucial for neuronal development, yet little is known regarding its early roles during hindbrain segmentation. We show that Pax6 expression is highly dynamic in rhombomeres, suggesting an early function in the hindbrain. Utilization of multiple gain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 3021–3031.
Published: 15 August 2012
... transcriptional network, which controls endocrine differentiation, is not well understood. Here, we show that microRNA-7 (miR-7) is specifically expressed in endocrine precursors and in mature endocrine cells. We further demonstrate that Pax6 is an important target of miR-7. miR-7 overexpression in developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (22): 4991–5001.
Published: 15 November 2011
... underscored the physiological importance of homeoprotein intercellular transfer in eye field development, axon guidance and retino-tectal patterning, and visual cortex plasticity. Here, we have used the embryonic chick neural tube to investigate a possible role for homeoprotein Pax6 transfer in...
Journal Articles
Journal: Development
Development (2011) 138 (3): 443–454.
Published: 01 February 2011
...Danielle Matsushima; Whitney Heavner; Larysa H. Pevny In humans, haploinsufficiency of either SOX2 or PAX6 is associated with microphthalmia, anophthalmia or aniridia. In this study, through the genetic spatiotemporal specific ablation of SOX2 on both wild-type and Pax6 -haploinsufficent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 4051–4060.
Published: 01 December 2010
... progenitor fates. Conversely, Pax6 has an opposing function to antagonize Shh signaling, which provides intrinsic resistance to Shh responses and is important to constrain the inductive capacity of the Shh gradient over time. Our data further suggest that patterning of floor plate cells and p3 progenitors is...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2895–2904.
Published: 01 September 2010
..., DNA binding and transcriptional reporter assays showed that Pph13 can bind and activate transcription via a perfect Pax6 homeodomain palindromic binding site and the Rhodopsin core sequence I (RCSI) found upstream of Drosophila Rhodopsin genes. In vivo studies indicate that Pph13 is necessary and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (3): 405–415.
Published: 01 February 2010
..., and for the apical localization of Vasp, a Mena family protein with F-actin anti-capping function that is also required for morphogenesis. Finally, we show that the expression of Shroom3 is dependent on the crucial lens-induction transcription factor Pax6. This provides a previously missing link...
Journal Articles
Journal: Development
Development (2009) 136 (17): 2977–2985.
Published: 01 September 2009
...April N. Smith; Leigh-Anne Miller; Glenn Radice; Ruth Ashery-Padan; Richard A. Lang The transcription factors Pax6 and Sox2 have been implicated in early events in lens induction and have been proposed to cooperate functionally. Here, we investigated the activity of Sox2 in lens induction and its...