... is segmented by the reiterative formation of endodermal outpocketings called pharyngeal pouches, the molecular network underlying the reiterative pattern remains unclear. Here, we show that pax1 plays crucial roles in pouch segmentation in medaka ( Oryzias latipes ) embryos. Importantly, pax1 expression...

...) Injected side of a 5.5-day old embryo. Pax1 expression is absent in a region that normally contains the developing scapula (dashed outline). (D) Untreated control side of the same embryo shows a Pax1 -expressing stripe of mesenchymal cells (arrow)that will give rise to the blade of the scapula. sb...

...Isabel Rodrigo; Robert E. Hill; Rudi Balling; Andrea Münsterberg; Kenji Imai We have previously shown that the paired-box transcription factors Pax1 and Pax9 synergistically act in the proper formation of the vertebral column. Nevertheless, downstream events of the Pax1/Pax9 action...

... of the shoulder girdle, with both somitic and lateral plate origins being proposed. Abnormal scapular development has been described in the naturally occurring undulated series of mouse mutants, which has implicated Pax1 in the formation of this bone. Here we addressed the development of the scapula, firstly...

... in the Uncx4 . 1 mutant will be required to gain a more detailed picture of the genes directly dependent on Uncx4 . 1 . The analysis of the Pax1/Pax9 double mutants may suggest a similar cellular program regulated by these two factors in the specification of the ventral sclerotomal structures ( Peters et...

...Heiko Peters; Bettina Wilm; Norio Sakai; Kenji Imai; Richard Maas; Rudi Balling The paralogous genes Pax1 and Pax9 constitute one group within the vertebrate Pax gene family. They encode closely related transcription factors and are expressed in similar patterns during mouse embryogenesis...

... of the dermomyotome. In contrast, the dorsomedial graft of a notochord inhibits cartilage differentiation of the dorsal part of the vertebra carrying the spinous process. Cartilage differentiation is preceded by the expression of transcription factors of the Pax family ( Pax1/Pax9 ) in the ventrolateral domain...

...-mail: s.dietrich@umds.ac.uk ) 04 04 1998 19 04 1998 © 1998 by Company of Biologists 1998 Somite Lateralisation Medialisation Dorsalisation Ventralisation Dermomyotome Myotome Sclerotome Hypaxial musculature Myoblast migration Chick Lbx1 MyoD Pax1 Pax3 Sim1 Bmp4...

... intrinsically controls its competence to respond to the external inducers. * Author for correspondence (e-mail: s.dietrich@umds.ac.uk ) 01 08 1997 © 1997 by Company of Biologists 1997 somite dorsalisation ventralisation dermomyotome myotome sclerotome chick MyoD Pax1...

...Johan Wallin; Hermann Eibel; Annette Neubüser; Jörg Wilting; Haruhiko Koseki; Rudi Balling ABSTRACT Pax1 is a transcriptional regulatory protein expressed during mouse embryogenesis and has been shown to have an important function in vertebral column development. Expression of Pax1 mRNA...