... in developing mesencephalon, in the brain of chick embryos by in ovo electroporation. Misexpression of Engrailed caused a rostral shift of the di-mesencephalic boundary, and caused transformation of dorsal diencephalon into tectum, a derivative of dorsal mesencephalon. Ectopic Engrailed rapidly repressed Pax-6...

... into abnormal brain outgrowths. At the same time, Xanf-1 can inhibit terminal differentiation of primary neurones. We also show that, during gastrula/ neurula stages, the exogenous Xanf-1 can downregulate four transcription regulators, XBF-1, Otx-2, Pax-6 and the endogenous Xanf-1 , that are expressed...

... that express high levels of Mash-1 , we studied Mash-1 mutant mice to assess the potential roles of these domains in TCA pathfinding. In null mutants, each of the domains is altered: the two Pax-6 domains, one in ventral thalamus and one in hypothalamus, are expanded in size; a complementary RPTP δ domain...

... play a role in lens bias and specification, and we focus on these roles here. Fate mapping shows that the transcriptional regulators Otx-2, Pax-6 and Sox-3 are expressed in the presumptive lens ectoderm prior to lens differentiation. Otx-2 appears first, followed by Pax-6 , during the stages of lens...

...Sacha Glardon; Linda Z. Holland; Walter J. Gehring; Nicholas D. Holland ABSTRACT Pax-6 genes have been identified from a broad range of invertebrate and vertebrate animals and shown to be always involved in early eye development. Therefore, it has been proposed that the various types of eyes...

...Georg Halder; Patrick Callaerts; Susanne Flister; Uwe Walldorf; Urs Kloter; Walter J. Gehring ABSTRACT The Drosophila Pax-6 gene eyeless acts high up in the genetic hierarchy involved in compound eye development and can direct the formation of extra eyes in ectopic locations. Here we identify sine...

... Patologica, Facultad de Medicina, Campus de Teatinos, 29071 Malaga, Spain 06 03 1998 06 05 1998 © 1998 by Company of Biologists 1998 Evolution Forebrain Telencephalon Brain Vertebrates Mouse Chick Turtle Frog Neural tube Emx-1 Dlx-1 Pax-6 Several features...

...Damira Carić; Douglas Gooday; Robert E. Hill; Susan K. McConnell; David J. Price ABSTRACT The cerebral cortex forms by the orderly migration and subsequent differentiation of neuronal precursors generated in the proliferative ventricular zone. We studied the role of the transcription factor Pax-6...

...Noriko Osumi; Arisa Hirota; Hideyo Ohuchi; Masato Nakafuku; Tadahiro Iimura; Shigeru Kuratani; Michio Fujiwara; Sumihare Noji; Kazuhiro Eto ABSTRACT Pax-6 is a member of the vertebrate Pax gene family, which is structurally related to the Drosophila pair-rule gene, paired . In mammals, Pax-6...

...Grant S. Mastick; Nicole M. Davis; Gracie L. Andrews; Stephen S. Easter, Jr ABSTRACT The Pax-6 gene encodes a transcription factor that is expressed in regionally restricted patterns in the developing brain and eye. Here we describe Pax-6 expression in the early forebrain (prosencephalon...

...Natasha Warren; David J. Price ABSTRACT Pax-6 is one of the earliest regulatory genes to be expressed in the diencephalon. We tested whether normal Pax-6 protein is required for early diencephalic development by examining morphology, precursor proliferation and patterns of regulatory gene...

...Justin C. Grindley; Duncan R. Davidson; Robert E. Hill ABSTRACT Small eye ( Sey ) mice homozygous for mutations in the Pax-6 gene have no lenses and no nasal cavities. We have examined the ontogeny of eye and nasal defects in Sey/Sey embryos and have related the defects seen to the pattern of Pax-6...

...Sacha Glardon; Patrick Callaerts; Georg Halder; Walter J. Gehring ABSTRACT The Pax-6 genes of vertebrates and invertebrates encode transcription factors with both a paired domain and a homeodomain. They are expressed in the developing eye and in the central nervous system. Loss-of-function...

...Justin C. Grindley; Duncan R. Davidson; Robert E. Hill ABSTRACT Small eye ( Sey ) mice homozygous for mutations in the Pax-6 gene have no lenses and no nasal cavities. We have examined the ontogeny of eye and nasal defects in Sey/Sey embryos and have related the defects seen to the pattern of Pax-6...