.... elegans , loss of the essential TORC2 component RICTOR ( rict-1 ) causes delayed development, shortened lifespan, reduced brood, small size and increased fat. Here, we report that knockdown of both the hedgehog-related morphogen grd-1 and its patched-related receptor ptr-11 rescues delayed development...

... by patched on target cells, transduced across the cell membrane by smoothened, and transmitted to the nucleus by GLI proteins to influence gene-expression programs. * Authors for correspondence ( [email protected] , [email protected] ) Competing interests The authors declare...

.... , Dressel , R. , Koleva , M. , Frommhold , A. , Zibat , A. , Binder , C. , Adham , I. , Nitsche , M. , et al. ( 2007 ). The Hedgehog receptor Patched controls lymphoid lineage commitment . Blood   110 , 1814 - 1823 . 10.1182/blood-2007-02-075648 Vankelecom , H...

... to adjacent cells of the anterior compartment. We monitored Hh:GFP after pulsed expression, and analyzed the movement and colocalization of Hh, Patched (Ptc) and Smoothened (Smo) proteins tagged with GFP or mCherry and expressed at physiological levels from bacterial artificial chromosome transgenes. Hh:GFP...

... abnormalities include hyperganglionosis, ectopic ganglia, and hypoganglionosis, which are often associated with intestinal dysmotility ( Kapur, 2000 ). Enteric nervous system Sonic hedgehog Patched Ptch Epithelium Extracellular matrix Enteric neural crest cells Hirschsprung disease Chick Quail...

... no competing financial interests. 31 10 2011 © 2012. Segmentation Muscle pattern Notch Patched Hedgehog Compartments Drosophila Most multicellular animals, such as arthropods, are largely built as a chain of homologous segments. In the past, those studying...

.... * Author for correspondence ( [email protected] ) Competing interests statement 3 12 2010 © 2011. BMP Smad BiFC Engrailed Patched Gli Sonic Hedgehog Myotome Muscle pioneers Zebrafish Members of the Hedgehog (Hh) family of signalling...

... of a patched homolog, At-ptc , that encodes a putative negative regulator of Hedgehog (Hh) signaling, prevented initiation of the symmetry-breaking cell migration. Knockdown of a smoothened homolog, At-smo , showed that Hh signaling inactivation also arrested the cells at the germ disc center, whereas moderate...

...Helena Khaliullina; Daniela Panáková; Christina Eugster; Falko Riedel; Maria Carvalho; Suzanne Eaton Hedgehog (Hh) is a lipoprotein-borne ligand that regulates both patterning and proliferation in a wide variety of vertebrate and invertebrate tissues. When Hh is absent, its receptor Patched (Ptc...

... interaction between these two signaling pathways, we have inactivated theβ-catenin gene and upregulated Ihh signaling simultaneously in the same cells during endochondral skeletal development using β-catenin and patched 1 floxed alleles. We uncovered previously unexpected roles of Ihh signaling in synovial...

...) in the developing cerebellum, but little is known about the early stages of the disease. Here, we identify a pre-neoplastic stage of medulloblastoma in patched heterozygous mice, a model of the human disease. We show that pre-neoplastic cells are present in the majority of patched mutants,although only 16...

... of lens precursors express genes characteristic of pituitary cells. However, overexpression of shh does not increase median pituitary placode size nor does it upregulate patched ( ptc ) expression in pituitary precursors during early somitogenesis. Our study suggests that by the end of gastrulation, pitx3...

... plays a key role in hedgehog signaling in the early mouse embryo. Here we have used a hypomorphic allele in Disp1(Disp1 Δ 2 ) , to extend our knowledge of Disp1 function in Hh-mediated patterning of the mammalian embryo. Through genetic combinations with null alleles of patched 1 ( Ptch1 ),sonic...

...Carlos Torroja; Nicole Gorfinkiel; Isabel Guerrero The Hedgehog (Hh) morphogenetic gradient controls multiple developmental patterning events in Drosophila and vertebrates. Patched (Ptc), the Hh receptor, restrains both Hh spreading and Hh signaling. We report how endocytosis regulates...

... is in a complex that contains all of the known Hh cytoplasmic components, including Cubitus interruptus (Ci)the only known target of Hh signaling. Hh promotes the entry of Sxl into the nucleus in the wing disc. In the anterior compartment, the Hh receptor Patched(Ptc) is required for this effect, revealing Ptc...

... activity has to be regulated tightly to ensure proper pancreas development. We have analyzed the function of two hedgehog inhibitors, Hhip and patched 1 (Ptch),during pancreas formation. Our results indicated that loss of Hhip results in increased hedgehog signaling within the pancreas anlage. Pancreas...

... culture Notochord patched Neurulation is the embryonic process in which the neural plate, a specialised region of ectoderm on the dorsal surface of the embryo, undergoes shaping and folding to form the neural tube. Failure of neural tube closure leads to clinically important birth defects...

... to be necessary for the action of heparan sulphate. In situ hybridisation analysis demonstrates a normal distribution of sonic hedgehog mRNA in chlorate-treated embryos. By contrast, patched 1 transcripts are abnormally abundant in the notochord, and diminished in the overlying neuroepithelium, suggesting...

...Baragur V. Shyamala; Krishna Moorthi Bhat The transmembrane receptor Patched regulates several developmental processes in both invertebrates and vertebrates. In vertebrates, Patched also acts as a tumor suppressor. The Patched pathway normally operates by negatively regulating Smoothened, a G...

... in patterning the tracheal branches. Hh is expressed in segmental stripes abutting the anterior border of the tracheal placodes. Induction of patched expression, which results from activation by Hh, demonstrates that cells in the anterior half of the tracheal pit are activated. In hh -mutant embryos migration...