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Keywords: Patched
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Journal Articles
Journal: Development
Development (2023) 150 (24): dev201974.
Published: 11 December 2023
.... elegans , loss of the essential TORC2 component RICTOR ( rict-1 ) causes delayed development, shortened lifespan, reduced brood, small size and increased fat. Here, we report that knockdown of both the hedgehog-related morphogen grd-1 and its patched-related receptor ptr-11 rescues delayed development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev166892.
Published: 15 May 2019
... by patched on target cells, transduced across the cell membrane by smoothened, and transmitted to the nucleus by GLI proteins to influence gene-expression programs. * Authors for correspondence ( rrohatgi@stanford.edu , christian@strubi.ox.ac.uk ) Competing interests The authors declare...
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (17): 3134–3144.
Published: 1 September 2017
... to adjacent cells of the anterior compartment. We monitored Hh:GFP after pulsed expression, and analyzed the movement and colocalization of Hh, Patched (Ptc) and Smoothened (Smo) proteins tagged with GFP or mCherry and expressed at physiological levels from bacterial artificial chromosome transgenes. Hh:GFP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 264–275.
Published: 15 January 2016
... abnormalities include hyperganglionosis, ectopic ganglia, and hypoganglionosis, which are often associated with intestinal dysmotility ( Kapur, 2000 ). Enteric nervous system Sonic hedgehog Patched Ptch Epithelium Extracellular matrix Enteric neural crest cells Hirschsprung disease Chick Quail...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 75–83.
Published: 1 January 2012
... switched the identity of patches of epidermal cells using genetic mosaics and altered muscle attachments accordingly. We also investigate what orients the muscles; these are mostly precisely arranged in the anteroposterior axis. In embryos, a signal from sr -expressing cells attracts the myotubes...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 755–765.
Published: 15 February 2011
.... * Author for correspondence ( pingham@imcb.a-star.edu.sg ) Competing interests statement 3 12 2010 © 2011. BMP Smad BiFC Engrailed Patched Gli Sonic Hedgehog Myotome Muscle pioneers Zebrafish Members of the Hedgehog (Hh) family of signalling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (8): 1263–1273.
Published: 15 April 2010
... of a patched homolog, At-ptc , that encodes a putative negative regulator of Hedgehog (Hh) signaling, prevented initiation of the symmetry-breaking cell migration. Knockdown of a smoothened homolog, At-smo , showed that Hh signaling inactivation also arrested the cells at the germ disc center, whereas moderate...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4111–4121.
Published: 15 December 2009
...Helena Khaliullina; Daniela Panáková; Christina Eugster; Falko Riedel; Maria Carvalho; Suzanne Eaton Hedgehog (Hh) is a lipoprotein-borne ligand that regulates both patterning and proliferation in a wide variety of vertebrate and invertebrate tissues. When Hh is absent, its receptor Patched (Ptc...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3695–3707.
Published: 15 September 2006
... interaction between these two signaling pathways, we have inactivated theβ-catenin gene and upregulated Ihh signaling simultaneously in the same cells during endochondral skeletal development using β-catenin and patched 1 floxed alleles. We uncovered previously unexpected roles of Ihh signaling in synovial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2425–2439.
Published: 15 May 2005
...) in the developing cerebellum, but little is known about the early stages of the disease. Here, we identify a pre-neoplastic stage of medulloblastoma in patched heterozygous mice, a model of the human disease. We show that pre-neoplastic cells are present in the majority of patched mutants,although only 16...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (7): 1579–1590.
Published: 1 April 2005
... of lens precursors express genes characteristic of pituitary cells. However, overexpression of shh does not increase median pituitary placode size nor does it upregulate patched ( ptc ) expression in pituitary precursors during early somitogenesis. Our study suggests that by the end of gastrulation, pitx3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (16): 4021–4033.
Published: 15 August 2004
... plays a key role in hedgehog signaling in the early mouse embryo. Here we have used a hypomorphic allele in Disp1(Disp1 Δ 2 ) , to extend our knowledge of Disp1 function in Hh-mediated patterning of the mammalian embryo. Through genetic combinations with null alleles of patched 1 ( Ptch1 ),sonic...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (20): 4871–4879.
Published: 15 October 2003
... activity has to be regulated tightly to ensure proper pancreas development. We have analyzed the function of two hedgehog inhibitors, Hhip and patched 1 (Ptch),during pancreas formation. Our results indicated that loss of Hhip results in increased hedgehog signaling within the pancreas anlage. Pancreas...
Journal Articles
Journal: Development
Development (2002) 129 (10): 2507–2517.
Published: 15 May 2002
... signaling in cranial as well as spinal neurulation. *Author for correspondence (e-mail: a.copp@ich.ucl.ac.uk ) 27 2 2002 © 2002. 2002 Neurulation Neural plate Morphogenesis Embryo culture Notochord patched Neurulation is the embryonic process in which the neural...
Journal Articles
Journal: Development
Development (2002) 129 (9): 2109–2119.
Published: 1 May 2002
... to be necessary for the action of heparan sulphate. In situ hybridisation analysis demonstrates a normal distribution of sonic hedgehog mRNA in chlorate-treated embryos. By contrast, patched 1 transcripts are abnormally abundant in the notochord, and diminished in the overlying neuroepithelium, suggesting...
Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (9): 1599–1606.
Published: 1 May 2001
... in patterning the tracheal branches. Hh is expressed in segmental stripes abutting the anterior border of the tracheal placodes. Induction of patched expression, which results from activation by Hh, demonstrates that cells in the anterior half of the tracheal pit are activated. In hh -mutant embryos migration...