... refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells for application in disease modeling, diagnostics, drug screening and cell-based therapies for Parkinson's disease. An increased understanding of the timing and molecular mechanisms that promote...

... by The Company of Biologists Ltd 2020 Summary: This short Spotlight summarizes the current state of pre-clinical and clinical research using pluripotent stem cells for regenerative therapy, and the influence of developmental biology-inspired approaches. Cardiomyopathy Diabetes Parkinson's disease...

...Malin Parmar ABSTRACT Treating neurodegenerative diseases with cell transplantation has been within reach since the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain were transplanted to individuals with Parkinson's disease. However, the use of fetal tissue...

... that the retromer complex is involved in specific developmental processes. Moreover, a number of recent studies implicate aberrant retromer function in photoreceptor degeneration, Alzheimer's disease and Parkinson's disease. Here, and in the accompanying poster, we provide an overview of the molecular and cellular...

..., such as Parkinson's disease (PD), might be facilitated by a better understanding of how these neurons are specified, differentiated and maintained in vivo . This knowledge might help to instruct efforts to generate mDA neurons in vitro , which holds promise not only for cell replacement therapy, but also for disease...

... Competing interests statement The authors declare no competing financial interests. 11 6 2012 © 2012. Midbrain Neuronal migration Parkinson’s disease Neuronal migration is a fundamental process in the development of the central nervous system because neurons eventually...

.... 24 4 2012 © 2012. Parkinson’s disease Dopamine neurons Nurr1 Neuronal maturation Doxycycline inducible expression system NPCs were cultured as previously described ( Park et al., 2008 ). NPCs derived from the cortex of rat embryos at embryonic day (E) 14 were grown...

...Frank M. J. Jacobs; Susan van Erp; Annemarie J. A. van der Linden; Lars von Oerthel; J. Peter H. Burbach; Marten P. Smidt In recent years, the meso-diencephalic dopaminergic (mdDA) neurons have been extensively studied for their association with Parkinson's disease. Thus far, specification...

...Daniela Omodei; Dario Acampora; Pietro Mancuso; Nilima Prakash; Luca Giovanni Di Giovannantonio; Wolfgang Wurst; Antonio Simeone Meso-diencephalic dopaminergic (mdDA) neurons control voluntary movement,cognition and the reward response, and their degeneration is associated with Parkinson's disease...

... issues for realizing safe and efficient cell transplantation therapies for Parkinson's disease. Although recent studies have identified the factors that regulate mesDA neuron development, the mechanisms underlying mesDA neuron specification are not fully understood. Recently, it has been suggested...

...Clare L. Parish; Anna Beljajeva; Ernest Arenas; András Simon Death and lack of functional regeneration of midbrain dopaminergic (DA)neurons, decreased DA input in the target striatum and movement anomalies characterise Parkinson's disease (PD). There is currently no cure for PD. One way to promote...

...Frank M. J. Jacobs; Simone M. Smits; Cornelle W. Noorlander; Lars von Oerthel; Annemarie J. A. van der Linden; J. Peter H. Burbach; Marten P. Smidt Selective neuronal loss in the substantia nigra (SNc), as described for Parkinson's disease (PD) in humans and for Pitx3 deficiency in mice,highlights...

... ‡ These authors contributed equally to this work 25 11 2005 ©2006. 2006 Proneural genes Cell fate specification Differentiation Sox2 Nurr1 Stem cells Parkinson's disease During the initial phases of nervous system development, progenitor cells in the neural tube proliferate...

... abnormalities in the ventral midbrain. † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 25 11 2005 ©2006. 2006 Parkinson's disease Proneural genes Differentiation Midbrain Tyrosine hydroxylase Mouse...