... as paraxial mesoderm. By contrast, haemogenic potential is well established for extra-embryonic mesoderm and intra-embryonic lateral plate mesoderm, which do not express Pax3 . To date, it is not known whether the haematopoietic system also contains Pax3 lineage cells. Here, we show that the mouse foetal...

... and commitment to the generation of PRG4 -expressing permanent cartilage, has been developed from human pluripotent stem cells and characterized at the molecular level. Pluripotent stem cell Paraxial mesoderm Chondrocyte Hypertrophy Mineralization Joint Interzone Articular cartilage Ligament...

...-ventral patterning Hb9 Motoneurons Myotome Neural tube Nkx Paraxial mesoderm Olig2 Pax7 Retinoic acid Somite Summary: Loss- and gain-of-function, and floor plate deletions, reveal that Shh that transits through the sclerotome is presented to the neuroepithelium from its basal aspect...

... myotome . Dev. Dyn.   235 , 1884 - 1894 . 10.1002/dvdy.20832 Aulehla , A. and Pourquié , O. ( 2010 ). Signaling gradients during paraxial mesoderm development . Cold Spring Harb. Perspect Biol.   2 , a000869 . 10.1101/cshperspect.a000869 Awaya , T. , Kato , T...

... Body skeletal muscles derive from the paraxial mesoderm, which forms in the posterior region of the embryo. Using microarrays, we characterize novel mouse presomitic mesoderm (PSM) markers and show that, unlike the abrupt transcriptome reorganization of the PSM, neural tube differentiation...

... lateral plate differentiation is profoundly altered. During this period, global mRNA levels are unchanged in the PSM, with only a minor subset of genes dysregulated. Together, our data strongly suggest that the TAF10-containing canonical TFIID and SAGA complexes are dispensable for early paraxial mesoderm...

... of Biologists Ltd 2017 Summary: This Review discusses the mechanisms that underpin the formation of skeletal muscle during development and its recapitulation from pluripotent stem cells in vitro . Skeletal myogenesis Muscle differentiation Paraxial mesoderm Somite Dermomyotome Muscular...

... and Hamilton) in the newly ingressed paraxial mesoderm (data not shown). From the onset of somitogenesis (stage 7HH; day 1) to the end (stage 24HH; day 4), PAPC expression formed a marked, decreasing rostrocaudal gradient along the PSM, with two or three stripes in the anterior PSM ( Fig. 1 C-F). PAPC mRNA...

...Robert J. Garriock; Ravindra B. Chalamalasetty; Mark W. Kennedy; Lauren C. Canizales; Mark Lewandoski; Terry P. Yamaguchi In the development of the vertebrate body plan, Wnt3a is thought to promote the formation of paraxial mesodermal progenitors (PMPs) of the trunk region while suppressing neural...

... 2014 © 2014. Published by The Company of Biologists Ltd 2014 bHLH transcription factor Paraxial mesoderm PSM Differentiation EMT Motility Wnt Embryonic stem cell Somite Mouse The process of vertebrate body formation provides an excellent opportunity to understand...

...Jiangang Zhao; Songhui Li; Suprita Trilok; Makoto Tanaka; Vanta Jokubaitis-Jameson; Bei Wang; Hitoshi Niwa; Naoki Nakayama Pluripotent embryonic stem cells (ESCs) generate rostral paraxial mesoderm-like progeny in 5-6 days of differentiation induced by Wnt3a and Noggin (Nog). We report...

... tail somites. Through its combined effects on gene expression and cell movement, Msgn1 (with Spt) plays a key role both in genesis of the paraxial mesoderm and in maintenance of the progenitor population from which it derives. References Amacher S. L. , Draper B. W. , Summers B. R...

... patterning, in which Wnt3a from the paraxial mesoderm induces posterior cell fates via direct activation of a crucial transcription factor in the overlying neural plate. Embryos at the one-cell stage were injected with THVGR mRNA. Animal cap (AC) explants were removed at blastula stages for culture...

...) lateral plate mesoderm. The reporter was also expressed in hindgut endoderm.( D , E ) In posterior regions of the embryo, Hoxb6-cre had a broader expression domain and the reporter was also expressed in paraxial mesoderm cells (arrowheads in E; E shows boxed area in D) and cells in the neural plate...

..., 600 Main Street, Bar Harbor, ME 04609, USA 1 2 2007 © 2007. 2007 Myotome Anterior border cells Cell fate Paraxial mesoderm Somite Dermomyotome Zebrafish Fast muscle Pax7 Myogenesis Teleost Recently, we and others proposed that cells expressing Pax3 and Pax7...

... in mesoderm development. Unlike Bmpr1a -null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character...

... and amphibian embryos. Here, we analyze the molecular mechanisms of neural crest induction by the mesoderm in Xenopus embryos. Using a recombination assay, we show that prospective paraxial mesoderm induces a panel of neural crest markers ( Slug, FoxD3, Zic5 and Sox9 ),whereas the future axial mesoderm only...

... temporal activation of expression and the establishment of the correct anterior boundary in the paraxial mesoderm (somite 6/7). However, the Hoxb4 promoter is required to maintain this expression beyond 8.5 dpc. In addition, sequences within the 3′ untranslated region (region B)are necessary specifically...

... somite polarity markers are not expressed in fss mutant embryos; instead, markers of posterior polarity are expressed throughout the paraxial mesoderm ( Durbin et al., 2000 ). In other zebrafish mutants, such as bea, des, mib and aei/deltaD , cells expressing anterior and posterior markers...

... environment. Results from experiments in which posterior neural segments and/or paraxial mesoderm segments were placed at different axial levels suggest that signals setting Hoxd10 expression form a decreasing posterior-to-anterior gradient. Our experiments do not, however, implicate adjacent paraxial...