... as paraxial mesoderm. By contrast, haemogenic potential is well established for extra-embryonic mesoderm and intra-embryonic lateral plate mesoderm, which do not express Pax3 . To date, it is not known whether the haematopoietic system also contains Pax3 lineage cells. Here, we show that the mouse foetal...

.../dev.117580 Umeda , K. , Zhao , J. , Simmons , P. , Stanley , E. , Elefanty , A. and Nakayama , N. ( 2012 ). Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells . Sci. Rep. 2 , 455 . 10.1038...

... tube Nkx Paraxial mesoderm Olig2 Pax7 Retinoic acid Somite Summary: Loss- and gain-of-function, and floor plate deletions, reveal that Shh that transits through the sclerotome is presented to the neuroepithelium from its basal aspect to affect motoneuron development. © 2020...

... , O. ( 2010 ). Signaling gradients during paraxial mesoderm development . Cold Spring Harb. Perspect Biol.   2 , a000869 . 10.1101/cshperspect.a000869 Awaya , T. , Kato , T. , Mizuno , Y. , Chang , H. , Niwa , A. , Umeda , K. , Nakahata , T. and Heike , T...

... Body skeletal muscles derive from the paraxial mesoderm, which forms in the posterior region of the embryo. Using microarrays, we characterize novel mouse presomitic mesoderm (PSM) markers and show that, unlike the abrupt transcriptome reorganization of the PSM, neural tube differentiation...

... lateral plate differentiation is profoundly altered. During this period, global mRNA levels are unchanged in the PSM, with only a minor subset of genes dysregulated. Together, our data strongly suggest that the TAF10-containing canonical TFIID and SAGA complexes are dispensable for early paraxial mesoderm...

... of Biologists Ltd 2017 Summary: This Review discusses the mechanisms that underpin the formation of skeletal muscle during development and its recapitulation from pluripotent stem cells in vitro . Skeletal myogenesis Muscle differentiation Paraxial mesoderm Somite Dermomyotome Muscular...

... in the developing chick embryo by promoting CDH2 (N-cadherin) endocytosis. Somitogenesis Tissue morphogenesis Cell adhesion Cadherin Protocadherin Paraxial mesoderm Boundary formation Endocytosis Stowers Institute for Medical Research 10.13039/100007795 Howard Hughes Medical...

...Robert J. Garriock; Ravindra B. Chalamalasetty; Mark W. Kennedy; Lauren C. Canizales; Mark Lewandoski; Terry P. Yamaguchi In the development of the vertebrate body plan, Wnt3a is thought to promote the formation of paraxial mesodermal progenitors (PMPs) of the trunk region while suppressing neural...

... , D. , Papaioannou , V. E. and Hadjantonakis , A.-K. ( 2012 ). Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo . Dev. Biol. 367 , 1 - 14 . 10.1016/j.ydbio.2012.04.012 Palmer...

...Jiangang Zhao; Songhui Li; Suprita Trilok; Makoto Tanaka; Vanta Jokubaitis-Jameson; Bei Wang; Hitoshi Niwa; Naoki Nakayama Pluripotent embryonic stem cells (ESCs) generate rostral paraxial mesoderm-like progeny in 5-6 days of differentiation induced by Wnt3a and Noggin (Nog). We report...

... tail somites. Through its combined effects on gene expression and cell movement, Msgn1 (with Spt) plays a key role both in genesis of the paraxial mesoderm and in maintenance of the progenitor population from which it derives. During segmentation, Ntl, Wnt and Fgf positively regulate msgn1...

... patterning, in which Wnt3a from the paraxial mesoderm induces posterior cell fates via direct activation of a crucial transcription factor in the overlying neural plate. To further investigate this regulation, we examined the Meis3 gene promoter. We cloned a 6.5 kb Meis3 gene fragment. This region...

... plate mesoderm. † Author for correspondence (e-mail: [email protected] ) * Present address: Division of Vascular Surgery, University of Cologne,Cologne, Germany 17 3 2008 © 2008. 2008 Vascular smooth muscle cell Aorta Lateral plate mesoderm Paraxial mesoderm...

...,Tierra del Fuego, Argentina † Current address: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA 1 2 2007 © 2007. 2007 Myotome Anterior border cells Cell fate Paraxial mesoderm Somite Dermomyotome Zebrafish Fast muscle Pax7 Myogenesis Teleost...

... in mesoderm development. Unlike Bmpr1a -null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character...

... and amphibian embryos. Here, we analyze the molecular mechanisms of neural crest induction by the mesoderm in Xenopus embryos. Using a recombination assay, we show that prospective paraxial mesoderm induces a panel of neural crest markers ( Slug, FoxD3, Zic5 and Sox9 ),whereas the future axial mesoderm only...

... temporal activation of expression and the establishment of the correct anterior boundary in the paraxial mesoderm (somite 6/7). However, the Hoxb4 promoter is required to maintain this expression beyond 8.5 dpc. In addition, sequences within the 3′ untranslated region (region B)are necessary specifically...

... potential downstream components of Notch signaling are lacking in her1+7 -deficient embryos, somite boundaries form, but do so with a one and a half to two segment periodicity. ‡Author for correspondence (e-mail: [email protected] ) 9 5 2002 © 2002. 2002 Paraxial mesoderm...

... environment. Results from experiments in which posterior neural segments and/or paraxial mesoderm segments were placed at different axial levels suggest that signals setting Hoxd10 expression form a decreasing posterior-to-anterior gradient. Our experiments do not, however, implicate adjacent paraxial...