... as major regulators of bsx expression in the pineal complex. Upon loss of Bsx through the generation of a targeted mutation, embryos fail to form a parapineal organ and develop right-isomerized habenulae. Crucial enzymes in the melatonin biosynthesis pathway are not expressed, suggesting the absence...

... are regulated by a network of at least three transcription factors: Tbx2b, Flh and Nr2e3. Flh Nr2e3 Parapineal organ Pineal complex Tbx2b Zebrafish The development of the vertebrate nervous system proceeds via a series of well-conserved steps during which the correct numbers of neurons...