... or dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are crucial for establishing and maintaining adult endocrine cell function. However, during pancreas development, MafB is not only expressed in insulin- and glucagon-producing cells, but also in Neurog3 + endocrine...

... in the pancreas from fetal to adult stages. We identified a core set of developmentally conserved PDX1-bound genes that reveal the broad multifaceted role of PDX1 in pancreas development. Despite the well-known dramatic changes in PDX1 function and expression, we found that PDX1-bound genes are largely conserved...

... with GRGs; however, the in vivo role of GRG-mediated transcriptional repression in pancreas development is still not well understood. In this study, we used complex mouse genetics and transcriptomic analyses to determine that GRG3 is essential for β cell development, and in the absence of Grg3...

.../ Summary: Mutations in RFX6 cause the rare disorder Mitchell-Riley syndrome, which is characterised by pancreatic hypoplasia and neonatal diabetes, and is due to an early failure to form pancreatic endoderm. Genetic disease In vitro differentiation Mitchell-Riley syndrome Pancreas development...

.... β cell differentiation Retinoic acid signaling Wnt signaling Pancreas development Diabetes δ cell specification Cell signaling pathways are used continuously throughout development and adulthood to mediate tissue interactions and precisely control gene expression. In particular...

... investigated the heretofore unknown role of Ogt in exocrine and endocrine islet development. By genetic manipulation in vivo and by using morphometric and molecular analyses, such as immunofluorescence imaging and single cell RNA sequencing, we show the first evidence that Ogt regulates pancreas development...

... to define pancreatic cell fate transitions. This resource allows dynamic profiling of embryonic pancreas development at single cell resolution and reveals novel gene signatures during pancreatic differentiation into α- and β-cells. * These authors contributed equally to this work ‡ Author...

.... While intensive research has explored the signaling pathways and transcriptional programs that govern pancreas development, much remains to be discovered regarding the cellular processes that orchestrate pancreas morphogenesis. Here, we discuss the developmental mechanisms and principles that are known...

... pancreas development . Genes Dev. 17 , 2591 - 2603 . 10.1101/gad.269003 Collombat P. , Hecksher-Sorensen J. , Broccoli V. , Krull J. , Ponte I. , Mundiger T. , Smith J. , Gruss P. , Serup P. , Mansouri A. ( 2005 ). The simultaneous loss of Arx...

... is direct or indirect due to the increased neural cell numbers. First, we treated pancreas explants with neurturin (NRTN), another member of the GDNF ligand family. GFRα2, the preferential co-receptor for NRTN, is expressed in neuronal, but not epithelial, cells during pancreas development ( supplementary...

... of Stard13 expression in the pancreas disrupts epithelial morphogenesis and tip-domain organisation, resulting in hampered proliferation of tip progenitors and subsequent organ hypoplasia. Stard13 acts by regulating Rho signalling spatially and temporally during pancreas development. Our findings provide new...

...Sharon Kredo-Russo; Amitai D. Mandelbaum; Avital Ness; Ilana Alon; Kim A. Lennox; Mark A. Behlke; Eran Hornstein Genome-encoded microRNAs (miRNAs) provide a post-transcriptional regulatory layer that is important for pancreas development. However, how specific miRNAs are intertwined...

..., indicating a perfusion-independent mechanism. Thus, the vasculature controls pancreas morphogenesis and growth by reducing branching and differentiation of primitive epithelial cells. * Author for correspondence ( [email protected] ) 26 8 2011 © 2011. Pancreas development...

... division and is required for the first embryonic divisions, whereas Cdks 2, 4 and 6 are dispensable for organogenesis but vital for tissue-specific cell development. Here, we illustrate an important role for Cdk4 in regulating early pancreas development. Pancreatic development involves extensive...

... to acinar cells. To explain this observation we re-examined early events in pancreas formation. The pancreatic anlage that gives rise to the exocrine pancreas is located in the ventral gut endoderm (called the ventral bud). Ptf1a is a gene required for exocrine pancreas development and is first expressed...

... specification culminate in a severe reduction of pancreas mass and postnatal lethality. By contrast, inducing the stabilized form of β-catenin at a later time point in pancreas development causes enhanced proliferation that results in a dramatic increase in pancreas organ size. Taken together, these data...