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Keywords: Pancreas
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Journal Articles
Journal: Development
Development (2021) 148 (6): dev196964.
Published: 21 March 2021
... that the clustered protocadherin genes are differentially expressed during pancreas development. Pcdhγ genes are preferentially expressed in pancreatic endoderm, Pcdhβ genes in nascent islets, and Pcdhα genes in mature β-cells. Second, after extracting sub-networks of transcriptional regulators for each...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev179051.
Published: 12 April 2020
... ) Competing interests The authors declare no competing or financial interests. In the pancreas field, many studies have used single-cell technology to resolve key issues that have been unresolved by cell population-based studies, and to provide insights into β-cell neogenesis, maturation, regeneration...
Journal Articles
Journal: Development
Development (2020) 147 (6): dev186213.
Published: 30 March 2020
... pancreatic genetics, development and islet function could limit progress in developing interventions for human diseases such as diabetes mellitus. Similarities of pancreas morphology and function suggest that porcine and human pancreas developmental biology may have useful homologies. However, little...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev173674.
Published: 04 November 2019
... in tissue architecture and function. Pancreas Vasculature Beta cells VEGF Zebrafish Specialized to sense and rapidly respond to circulating metabolites, pancreatic islets are crucial in regulating glucose homeostasis. Attesting to their importance, these endocrine cell clusters are densely...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev165480.
Published: 15 August 2018
... of cells present in the human fetal pancreas and their lineage relationships, we developed strategies to isolate pancreatic progenitors, endocrine progenitors and endocrine cells. Transcriptome analysis of the individual populations revealed a large degree of conservation among vertebrates in the drivers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev161372.
Published: 08 June 2018
...Maja B. Gere-Becker; Claudia Pommerenke; Thomas Lingner; Tomas Pieler ABSTRACT Retinoic acid (RA) is required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA signalling in this context remains to be defined. By RNA sequencing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (3): dev158477.
Published: 08 February 2018
... of imaging internal organs with cellular resolution. Within transparent zebrafish larvae, the developing pancreas is relatively superficial and thus amenable to live imaging approaches. We performed in vivo time-lapse and longitudinal imaging studies to follow islet development, visualizing both naturally...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2402–2414.
Published: 01 July 2017
...Katie L. Sinagoga; William J. Stone; Jacqueline V. Schiesser; Jamie I. Schweitzer; Leesa Sampson; Yi Zheng; James M. Wells While much is known about the molecular pathways that regulate embryonic development and adult homeostasis of the endocrine pancreas, little is known about what regulates early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3573–3581.
Published: 01 October 2016
... ). Chromatin immunoprecipitation analysis of Xenopus embryos . Methods Mol. Biol.   917 , 279 - 292 . 10.1007/978-1-61779-992-1_17 Avrahami , D. and Kaestner , K. H. ( 2012 ). Epigenetic regulation of pancreas development and function . Semin. Cell Dev. Biol.   23 , 693 - 700 . 10.1016...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 780–786.
Published: 01 March 2016
...Shouhong Xuan; Lori Sussel GATA4 and GATA6 are zinc finger transcription factors that have important functions in several mesodermal and endodermal organs, including heart, liver and pancreas. In humans, heterozygous mutations of either factor are associated with pancreatic agenesis; however...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3126–3137.
Published: 15 September 2015
...Rachel E. Jennings; Andrew A. Berry; James P. Strutt; David T. Gerrard; Neil A. Hanley A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here...
Journal Articles
Journal: Development
Development (2015) 142 (8): 1407–1417.
Published: 15 April 2015
.... , Hesselson , D. , Dong , P. D. S. , Shin , D. , Chi , N. C. , Shin , C. H. , Schlegel , A. , Halpern , M. , et al. ( 2009 ). Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration . Dev. Biol.   334 , 213 - 223...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 858–870.
Published: 01 March 2015
... cell over-proliferation and cyst formation. Transcriptome comparison between WT and Bicc1 KO pancreata, before the phenotype onset, reveals that PKD2 functions downstream of BICC1 in preventing cyst formation in the pancreas. Moreover, the analysis highlights immune cell infiltration and stromal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 871–882.
Published: 01 March 2015
...Matias G. De Vas; Janel L. Kopp; Claire Heliot; Maike Sander; Silvia Cereghini; Cécile Haumaitre Heterozygous mutations in the human HNF1B gene are associated with maturity-onset diabetes of the young type 5 (MODY5) and pancreas hypoplasia. In mouse, Hnf1b heterozygous mutants do not exhibit any...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4385–4394.
Published: 15 November 2014
... of a presumed pancreatic-commitment transcription factor, Ptf1a, in embryonic mouse endoderm (Ptf1a EDD ) dramatically expanded the pancreatic gene regulatory network within the foregut. Ptf1a EDD temporarily suppressed Sox2 broadly over the anterior endoderm. Pancreas-proximal organ territories underwent full...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (16): 3123–3133.
Published: 15 August 2014
... are in the supplementary material methods ; primary and secondary antibodies are listed in supplementary material Table S1 . Comprehensive analysis of the mRNA population in E13.5 normal or Nr5a2 Δ P pancreas was performed by RNA-Seq, using total RNA pooled from three normal pancreases or pooled from three...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2669–2679.
Published: 01 July 2013
...Joseph J. Lancman; Natasha Zvenigorodsky; Keith P. Gates; Danhua Zhang; Keely Solomon; Rohan K. Humphrey; Taiyi Kuo; Linda Setiawan; Heather Verkade; Young-In Chi; Ulupi S. Jhala; Christopher V. E. Wright; Didier Y. R. Stainier; P. Duc Si Dong Although the liver and ventral pancreas are thought...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3363–3372.
Published: 15 September 2012
.... We show that pancreatic progenitor-specific ablation of Sox9 during early pancreas development causes pancreas-to-liver cell fate conversion. Sox9 deficiency results in cell-autonomous loss of the fibroblast growth factor receptor (Fgfr) 2b, which is required for transducing mesenchymal Fgf10 signals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2488–2499.
Published: 15 July 2012
...Hung Ping Shih; Janel L. Kopp; Manbir Sandhu; Claire L. Dubois; Philip A. Seymour; Anne Grapin-Botton; Maike Sander In the pancreas, Notch signaling is thought to prevent cell differentiation, thereby maintaining progenitors in an undifferentiated state. Here, we show that Notch renders progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1744–1753.
Published: 15 May 2012
... with the observation of Cras-Meneur et al. ( Cras-Meneur et al., 2009 ), in which Psen1/2 deficiency results in conversion of the entire Ngn3 + pool into an acinar fate, but only when the remaining pancreatic progenitors are not deficient in Psen1/2 . Notably, the wider elimination of Psen1/2 in pancreas allows...
Includes: Supplementary data