... during pharyngeal pouch formation in the zebrafish head. Eph-ephrin PAK Branching morphogenesis Craniofacial Pharyngeal pouches Zebrafish During development, epithelial tissues undergo morphogenesis to form elaborately branched organs. Whereas epithelial cells are characterized...

... kinase Pak exhibit a novel phenotype, in which two side-by-side cysts are encapsulated at a time, generating paired egg chambers. This striking phenotype originates in the pupal ovary, where the developing germarium is shaped by the basal stalk, a stack of cells formed by cell intercalation. The process...

...Juliane Melzer; Karoline F. Kraft; Rolf Urbach; Thomas Raabe The final size of the central nervous system is determined by precisely controlled generation, proliferation and death of neural stem cells. We show here that the Drosophila PAK protein Mushroom bodies tiny (Mbt) is expressed in central...

.... Moreover, basal bodies are mispositioned along both the apicobasal and planar polarity axes of mutant hair cells, and hair bundle orientation was uncoupled from the basal body position. We show that a non-ciliary function of Kif3a regulates localized cortical activity of p21-activated kinases (PAK), which...

... Paks . Biol. Cell 100 , 97 - 108 . Bagnat M. , Cheung I. , Mostov K. , Stainier D. ( 2007 ). Genetic control of single lumen formation in the zebrafish gut . Nat. Cell Biol. 9 , 954 - 960 . Bertet C. , Sulak L. , Lecuit T. ( 2004 ). Myosin...

... polarized cell migration through recruitment of Rac, Cdc42 and the serine/threonine kinase Pak, an effector for Rac and Cdc42, to the LE. We have used DC and the follicular epithelium to study the relationship between Pak and the Scrib complex at epithelial membranes undergoing changes in apicobasal...

... of cell adhesion in the early embryo and in NC cells during craniofacial development. * Author for correspondence (e-mail: [email protected] ) 18 1 2007 © 2007. 2007 Cartilage PAK Cortical actin Cytoskeleton Wound healing Craniofacial Tfap2a Ectomesenchyme Neural crest...

... and molecular mechanisms by which olfactory axons pathfind to their targets are poorly understood. We report here that the SH2/SH3 adapter Dock and the serine/threonine kinase Pak are necessary for the precise guidance of olfactory axons. Using antibody localization, mosaic analyses and cell-type specific...