...-rule genes and relative expression of the segment polarity genes), but differ in use-function (progressive versus simultaneous patterning) ( Love, 2007 ). They also share common descent: the involvement of pair-rule genes in arthropod segmentation is extensively documented, and is at least as old...

... generates a repeating sequence of pair-rule gene expression, and how this is converted into a segment-polarity pattern by ‘timing factor’ wavefronts associated with axial extension. We argue that the gene regulatory network that patterns segments may be relatively conserved, although the timing...

... , these transcription factors are expressed like simple timers within the blastoderm, whereas in Tribolium they form wavefronts that sweep from anterior to posterior across the germband. In Drosophila , all three are known to regulate pair-rule gene expression and influence the temporal progression of segmentation. We...

... homeoprotein may directly regulate the expression of most genes. * Author for correspondence (e-mail: [email protected] ) 08 09 1998 20 10 1998 © 1998 by Company of Biologists 1998 Drosophila melanogaster Homeoproteins Homeotic genes Pair-rule genes Positional...

... of transcripts encoded by the pair-rule genes fushi tarazu ( ftz ) and even-skipped ( eve ) and later by stripes encoded by the segment polarity genes engrailed ( en ) and wingless . Here, we show that the runt gene ( run ) is required to generate asymmetries within these parasegmental domains. Using a heat...

...Susan M. Parkhurst; David Ish-Horowicz ABSTRACT We have used the hunchback ( hb ) gap-gene promoter to drive ectopic expression of the pair-rule genes fushi tarazu ( fiz ), even-skipped ( eve ) and hairy ( h ). Unexpectedly, flies transformed with such constructs are viable, despite spatial...

...Stephanie H. Vavra; Sean B. Carroll ABSTRACT The examination of pair-rule gene expression in wildtype and segmentation mutant embryos has identified many, but not necessarily all, of the elements of the regulatory system that establish their periodic patterns. Here we have conducted a new type...

...Sean B. Carroll; Stephanie H. Vavra ABSTRACT We examined gene expression patterns in certain single and double pair-rule mutant embryos to determine which of the largely repressive pair-rule gene interactions are most likely to be direct and which interactions are probably indirect. From...

... regulation in addition to the transcriptional control known to be involved in expression of this gene. Consistent with these observations on ftz expression, two other pair-rule genes, even-skipped ( Frasch et al . 1987 ) and hairy ( Carroll et al . 1988 ), also display complex intermediate patterns...

...Philip Ingham; Peter Gergen ABSTRACT The pair-rule genes of Drosophila play a fundamental role in the generation of periodicity in the early embryo. We have analysed the transcript distributions of runt, hairy, even-skipped and fushi tarazu in single and double mutant embryos. The results indicate...