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Keywords: PTK7
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Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (7): 1361–1370.
Published: 1 April 2011
... fails and the neural tube remains open. These defects are typically associated with deficits in planar cell polarity (PCP) signaling in vertebrates. Consistent with this, we found that expression of Ptk7, which encodes a gene involved in PCP, is markedly reduced in Cdx1-Cdx2 double mutants...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1321–1327.
Published: 1 April 2011
... RACK1 as a novel interaction partner of PTK7, a regulator of planar cell polarity that is necessary for neural tube closure. RACK1 is likewise required for Xenopus neural tube closure. Further, explant assays suggest that PTK7 and RACK1 are required for neural convergent extension. Mechanistically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (12): 2039–2048.
Published: 15 June 2009
... cells as they exit the primitive streak. This cell shape change occurs prior to, and is required for, the subsequent onset of mediolaterally polarized protrusive activity. In embryos mutant for PTK7, a novel cell polarity protein, the normal cell elongation and alignment upon leaving the primitive...
Includes: Multimedia, Supplementary data