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Development (2015) 142 (5): 817–831.
Published: 01 March 2015
... how signaling molecules, mechanical signals and morphological cell features are integrated to regulate chondrogenesis and bone development. Chondrogenesis Chondrocyte hypertrophy Growth plate Sox9 Ihh PTHrP Fgfr3 * Authors for correspondence ( firstname.lastname@example.org...
Minoti Hiremath, Pamela Dann, Jennifer Fischer, Daniela Butterworth, Kata Boras-Granic, Julie Hens, Joshua Van Houten, Wei Shi, John Wysolmerski
Development (2012) 139 (22): 4239–4249.
Published: 15 November 2012
...Minoti Hiremath; Pamela Dann; Jennifer Fischer; Daniela Butterworth; Kata Boras-Granic; Julie Hens; Joshua Van Houten; Wei Shi; John Wysolmerski Parathyroid hormone-related protein (PTHrP) regulates cell fate and specifies the mammary mesenchyme during embryonic development. Loss of PTHrP or its...
Includes: Supplementary data
Development (2008) 135 (11): 1947–1956.
Published: 01 June 2008
...) and PTHrP signaling play crucial roles in regulating the onset of chondrocyte hypertrophy by forming a negative feedback loop, in which Ihh signaling regulates chondrocyte hypertrophy by controlling PTHrP expression. To understand whether there is a PTHrP -independent role of Ihh signaling in regulating...
Includes: Supplementary data
Sylvain Provot, Hervé Kempf, L. Charles Murtaugh, Ung-il Chung, Dae-Won Kim, Jay Chyung, Henry M. Kronenberg, Andrew B. Lassar
Development (2006) 133 (4): 651–662.
Published: 15 February 2006
...Sylvain Provot; Hervé Kempf; L. Charles Murtaugh; Ung-il Chung; Dae-Won Kim; Jay Chyung; Henry M. Kronenberg; Andrew B. Lassar Parathyroid hormone-related protein (PTHrP) is essential to maintain a pool of dividing, immature chondrocytes in the growth plate of long bones. In chick and mouse...
Tatsuya Kobayashi, Ung-il Chung, Ernestina Schipani, Michael Starbuck, Gerard Karsenty, Takenobu Katagiri, Dale L. Goad, Beate Lanske, Henry M. Kronenberg
Development (2002) 129 (12): 2977–2986.
Published: 15 June 2002
... column-forming proliferating cells (columnar chondrocytes), stop dividing and finally differentiate into hypertrophic cells. Indian hedgehog (Ihh), which is predominantly expressed in prehypertrophic cells, stimulates expression of parathyroid hormone (PTH)-related peptide (PTHrP) which negatively...
Development (2002) 129 (8): 1913–1924.
Published: 15 April 2002
... peptide (PTHrP) has been described in which hypertrophic differentiation is limited by a signal secreted from chondrocytes as they become committed to hypertrophy. In this negative-feedback loop, Ihh inhibits hypertrophic differentiation by regulating the expression of Pthrp , which in turn acts directly...
Eleonora Minina, Hans Markus Wenzel, Conny Kreschel, Seth Karp, William Gaffield, Andrew P. McMahon, Andrea Vortkamp
Development (2001) 128 (22): 4523–4534.
Published: 15 November 2001
...Eleonora Minina; Hans Markus Wenzel; Conny Kreschel; Seth Karp; William Gaffield; Andrew P. McMahon; Andrea Vortkamp During endochondral ossification, two secreted signals, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP), have been shown to form a negative feedback loop...