... upregulates phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (PTEN) expression to activate FoxO, thereby promoting proteolysis during molting in the lepidopteran insect Helicoverpa armigera . FoxO expression is increased during molting and metamorphosis. The knockdown of FoxO in fifth instar larvae...

... and PTEN control blood progenitor proliferation through a common TOR- and 4EBP-dependent pathway. Tsc2 or Pten deficiency in progenitors increases TOR signaling and causes LG overgrowth by increasing the number of actively dividing cells that accumulate high levels of phosphorylated (p) 4EBP during...

... they differentiate into interneurons. We found that the PI3K-Akt-mTorc1 pathway is selectively inactivated in migrating neuroblasts in the subventricular zone and rostral migratory stream, and activated when these cells reach the olfactory bulb. Postnatal deletion of Pten caused aberrant activation of the PI3K-Akt...

... is the lipid phosphatase DAF-18/PTEN, which can modulate PI3K pathway activity during neurodevelopment. Here, we identify a novel role for DAF-18 in promoting neurite outgrowth during development in Caenorhabditis elegans . We find that DAF-18 modulates the PI3K signaling pathway to activate DAF-16/FOXO...

... of the Nap1/WAVE complex to promote migration of the nascent mesoderm. In addition to migration phenotypes, Rac1 Δ epi cells fail to adhere to matrix, which leads to extensive cell death. Cell death is largely rescued in Rac1 Δ epi mutants that are heterozygous for a null mutation in Pten , providing evidence...

...Anyonya R. Guntur; Martina I. Reinhold; Joe Cuellar, Jr; Michael C. Naski Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a direct antagonist of phosphatidylinositol 3 kinase. Pten is a well recognized tumor suppressor and is one of the most commonly mutated genes in human...

... to be a downstream target of Alk5 in vivo and in vitro. Loss of Alk5 -mediated signaling also stimulated Pten gene expression and inhibited ERK phosphorylation in vivo. Using lung epithelial cells, we show that Alk5 -regulated Hes1 expression is stimulated through Pten and the MEK/ERK and PI3K/AKT pathways. Thus...

... of distal bowel aganglionosis induced by vitamin A deficiency in Rbp4 –/– animals. Furthermore, RA reduces phosphatase and tensin homolog (Pten) accumulation in migrating cells, whereas Pten overexpression slows ENS precursor migration. Collectively, these data support the hypothesis that vitamin...

...Guan Yang; Qiang Sun; Yan Teng; Fangfei Li; Tujun Weng; Xiao Yang Chondrocytes within the growth plates acclimatize themselves to a variety of stresses that might otherwise disturb cell fate. The tumor suppressor PTEN(phosphatase and tensin homolog deleted from chromosome 10) has been implicated...

... signalling antagonist PTEN, which stimulates cell growth in most developing tissues, produces a very different phenotype in nurse cells, inducing formation of highly enlarged lipid droplets. Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype...

... activity also triggers developmental quiescence independent of the insulin-like pathway. Our data suggest that these two signalling pathways converge on the C. elegans PTEN orthologue to coordinate germline proliferation with somatic development during dauer formation, via the regulation of AMPK and its...

... as a mechanism for abnormal laminar formation, the role of radial glia, which provide the environmental cues, in modulating neuronal migration is less clear. We provide evidence that loss of PTEN in Bergmann glia leads to premature differentiation of this crucial cell population and subsequently to extensive...

... is not known. We show that the lipid phosphatase PTEN directly binds to Baz in vitro and in vivo, and colocalizes with Baz in the apical cortex of epithelia and neuroblasts. PTEN is an important regulator of phosphoinositide turnover that antagonizes the activity of PI3-kinase. We show that Pten mutant ovaries...

...Tohru Kimura; Akira Suzuki; Yukiko Fujita; Kentaro Yomogida; Hilda Lomeli; Noriko Asada; Megumi Ikeuchi; Andras Nagy; Tak W. Mak; Toru Nakano The tumor suppressor gene PTEN , which is frequently mutated in human cancers, encodes a lipid phosphatase for phosphatidylinositol 3,4,5-triphosphate...

...Gang Li; Gertraud W. Robinson; Ralf Lesche; Hilda Martinez-Diaz; Zhaorong Jiang; Nora Rozengurt; Kay-Uwe Wagner; De-Chang Wu; Timothy F. Lane; Xin Liu; Lothar Hennighausen; Hong Wu PTEN tumor suppressor is frequently mutated in human cancers, including breast cancers. Female patients with inherited...

... present biochemical and genetic evidence that loss of the homolog of the tumor suppressor gene, Pten , results in increased PtdIns P 3 levels and that these increased levels are sufficient to compensate for the complete loss of the Insulin/insulin-like growth factor receptor function. This reduction...

...Silvia Marino; Paul Krimpenfort; Carly Leung; Hetty A. G. M. van der Korput; Jan Trapman; Isabelle Camenisch; Anton Berns; Sebastian Brandner PTEN is a tumour suppressor gene involved in cell cycle control, apoptosis and mediation of adhesion and migration signalling. Germline mutations of PTEN...

... pathway in differentiation but it is essential for normal growth. Loss of Lilli function causes an autonomous reduction in cell size and partially suppresses the increased growth associated with loss of PTEN function. These results suggest that Lilli acts in parallel with the Ras/MAPK and the PI3K/PKB...